The luciferase gene in the pGL3 basic-A1, pGL3 basic-A4, and pGL3 basic-B1 constructs were replaced with the GFP gene or the NS3
gene of Japanese encephalitis virus (JEV) or DenV2 between the Nco I and Xba I sites for GFP or NS3
The eukaryotic vector (pcDNA3.1) harboring the immunogenic and conserved region of HCV subtype la NS3
gene (1095-1379 aa.
Grakoui et al., "Evidence that the N-terminal domain of nonstructural protein NS3
from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein," Proceedings of the National Academy of Sciences of the United States of America, vol.
The isolated compounds 1-7 from the EtOAc extract were tested for their inhibitory activity against HCV PR using HCV NS3
protease inhibitor 2 as a positive control .
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Briefly, after the membrane was washed, the target proteins were accordingly probed with the antibody to HCV Core (1:2500) or NS3
One hundred and forty-five patients (90.6%) were successfully amplified with the NS3
fragments, 71% (103/145) of whom presented at least one PIs RAVs.
Kempf et al., "Relative replication capacity and selective advantage profiles of protease inhibitorresistant hepatitis C virus (HCV) NS3
protease mutants in the HCV genotype 1b replicon system," Antimicrobial Agents and Chemotherapy, vol.
ACH-2684 is a macrocyclic, noncovalent, reversible inhibitor of the NS3
Results of a novel serologic test of samples from horses for antibodies to the conserved nonstructural protein 3 (NS3
) showed an overall seropositivity of 35%, and 80 samples from dogs were negative by serologic testing and PCR.
The HCV NS3
antigen was detected with Immunohistochemical technique using monoclonal antibody against HCV NS3
ACTIVITY OF COMPOUNDS FROM CHINESE HERBAL MEDICINE RHODIOLA KIRILOWII (REGEL) MAXIM AGAINST HCV NS3