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Abbreviations: FFD, four flavonoids from Daphne genkwa: FCA, Freund's complete adjuvant; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NO, nitric oxide; NRU, neutral red uptake; LPS, lipopolysaccharide; DPPH, 2,2diphenyl-1-picrylhydrazyl; DXM, dexamethasone; TGP, total glucosides of paeony; RA, rheumatoid arthritis; AA, adjuvant arthritis; PG, prostaglandins; DMEM, Dulbecco's Modified Eagle's Medium; iNOS, nitrite oxidative synthase.
The NRU is expected to keep running until 2016, even as the 2010 federal budget devoted $48 million to study alternative approaches for medical isotope production, such as using cyclotrons.
Howe company (then responsible for building NRU, the latest Chalk River reactor).
It determined that AECL was in breach of its licence and would not allow the NRU to reopen.
There is a growing literature outlining fatal flaws in the NRU approach, which render it unsuitable as a policy framework.
Last month the team was awarded a distinction under the Government's NRU Warden Quality Standard.
Results of a validation study in Germany on two in vitro alternatives to the Draize eye irritation test, the HET-CAM test and the 3T3 NRU cytotoxicity test.
Ashington: Ron Self; Berwick: Jim Turner; Blyth: Roger Phillips; Border Park: Keith Robson; Gosforth: Malcolm Bell; Medicals: Dr Mel McQuillin; Morpeth: Bill Hewitt; North Shields: Alastair Shield; Ponteland: Bill Snaith; Prudhoe and Stocksfield: Alan Carr; Seghill: John Atherton; Wallsend: Brian Thirlaway; Whitley Bay Rockcliff: Lawrence Fletcher; NRU Coaching Committee: John Clark; Referees Society: Geoff Parkinson; Rugby Development Partnership: Chris Davy; Senior Rugby XV: Albert Stephenson.
Under the ILTSA, commercially reasonable efforts are required to maintain isotope production from the NRU reactor until such time as Nordion has established a satisfactory, long-term alternative supply.
The scheduled shutdown of the NRU reactor in 2016 and OSIRIS in France in 2018 is, however, a major threat for manufacturers.
Speaking at the launch, Metropolitan Namibia's financial director, Le-Anne van Zyl said the partnership with the NRU aims to enable the union to meet its objective of developing rugby at grassroots levels.
The current NRU shutdown--and the shutdown of November 2007--illustrates the fragility and unpredictability of the global medical-isotope supply system, and highlights the requirement for new research reactor capacity to deliver a reliable long-term supply of medical isotopes," said Steve West, president of MDS Nordion.
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