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The use of LPV/r and EFV (NRTI sparing group) was compared to LPV/r and two NRTIs (LPV/r group) and EFV and two NRTIs (EFV group), as initial therapy for HIV infection (26).
The WHO guidelines do not define specific criteria for the inclusion of INSTIs, NNRTIs or NRTIs into third-line ART regimens.
This can be described as a limitation, but in the study above-mentioned, it was shown that virological success was achieved in 80% of patients irrespective of used backbone NRTI .
This limitation can be justified by standard criteria currently using the protocol for treatment of adult HIV positive patients, which recommends that the initiation of ART is performed with 2 NRTI + NNRTI, particularly EFZ600 + ATC.
The difference between the treatment groups was most pronounced for participants who started therapy when their CD4 cell count was below 100 cells/[mm.sup.3], with participants taking AZT having a count that was 66 cells/[mm.sup.3] lower after 5 years compared with individuals taking an alternative NRTI.
Any of the following 2-drug NRTI combinations are recommended for use with the NNRTI:
Enfeksiyonun tedavisinde baslangicta NRTI'lerin kullanimi ve ardindan karma antiretroviral tedavi (kART) yaklasiminin kullanima girmesi, HIV ile iliskili olum ve hastaliklari belirgin duzeyde azaltmistir (4).
Although the number of ART-naive HIV-2-infected individuals commencing a triple NRTI regimen (zidovudine, lamuvidine and either tenofovir or abacavir) in the current report1 is small, there is a clear warning that such PI-sparing first-line ART for HIV-2 may be suboptimal.
One group (285 women) received a nucleoside reverse-transcriptase inhibitor (NRTI) regimen consisting of abacavir, zidovudine and lamivudine; the other group (275 women) received a proteaseinhibitor regimen consisting of lopinavir, ritonavir, zidovudine and lamivudine.
REVOVIR is a Nucleoside Reverse Transcriptase Inhibitor (NRTI).
Tacking on nucleosides gained some credence when combination antiretroviral therapy arrived, partly because evidence suggested even a partially active NRTI could add some oomph to salvage combos, and partly because mutant virus evoked by continuing NRTI pressure could be feebler than nonmutant virus or more susceptible to other NRTIs.
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