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Indications for the inclusion of RAL included low-level or higher resistance to DRV/r (MS [greater than or equal to] 15) or no active NRTIs being available (ABC, AZT and TDF MS [greater than or equal to] 30).
Predictors of NRTI resistance were gender, age, CD4 count, viral load at failure, dual ZDV+ddI therapy, unboosted and boosted PI, and previous NNRTI use.
NRTI = nucleoside analogues reverse transcriptase inhibitors.
The primary safety endpoint--time to initial episode of severe signs/symptoms or laboratory abnormality prior to discontinuation of NRTI assignment--was also similar between arms (P = .
Second-line NNRTI plus NRTI regimens are often not effective in such patients because of NRTI mutations, while boosted PI regimens in second-line ART may remain effective.
Enfeksiyon hastaliklari kliniginde NRTI (zidovudin 150 mg/gun + lamivudin 300 mg/gun) ve PI (lopinavir 400 mg/gun + ritonavir 100 mg/gun) tedavisi ile takip edilen hasta kemik mineral yogunlugu degerlendirilmesi icin klinigimize yonlendirilmis.
The NRTI and protease-inhibitor groups had similarly high rates of HIV-1 suppression at delivery (96% and 93%, respectively) and throughout breast-feeding (92% and 93%, respectively).
24-Week data from Study AVX201: a prospective, randomized, double-blind, dose-ranging phase IIb study of apricitabine in treatment-experienced patients with M184Vand NRTI resistance.
present 17 papers describing recent work in NRTI drug discovery, pharmacology, and development of viral drug resistance.
Rio DE JANEIRO -- The novel nucleoside reverse transcriptase inhibitor Reverset is poised to become the newest member of the oldest class of antiretroviral agents, with researchers reporting its promise for HIV-infected patients for whom current antiretroviral regimens have failed and who have NRTI resistance.
This module, titled "Lessons Learned: The Perils of Extrapolation--Combination NRTI Use" will be available for one year at: http://www.
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