GABPA

(redirected from NRF2)

GABPA

A gene on chromosome 21q21.3 that encodes the alpha subunit of the GA-binding protein, which forms a tetrameric complex with two beta subunits and stimulates transcription of target genes. The encoded protein may downregulate cytochrome oxidase expression and may play a role in nuclear control of mitochondrial function.

References in periodicals archive ?

Keywords: Peroxisome proliferator-activated receptor gamma (PPARI3), Nuclear regulatory factor 2 (NRF2), Oxidative stress, Developmental block, Maternal-to-zygotic transition.

Pioglitazone Mediated Reduction in Oxidative Stress and Alteration in Level of PPARI3, NRF2 and Antioxidant Enzyme Genes in Mouse Preimplantation Embryo during Maternal to Zygotic Transition

Nuclear factor erythroid-related factor 2 (Nrf2) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals (17,18).

Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate [H.sub.2][O.sub.2]-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation

Next, nuclear factor erythroid 2-related factor 2 (Nrf2) was knocked down with Nrf2 small interfering RNA (siRNA) to confirm the specific role of Nrf2 in mucin regulation of CUR in NCI-H292 cells.

Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2

LifeVantage will initially offer its complete TrueScience Beauty System - the company's popular line of Nrf2-enhanced skin care products - with its flagship Protandim Nrf2 Synergizer anticipated to follow in the near future.

LifeVantage opens for business in Taiwan

They have shown for the first time that the transcription factor Nrf2 largely mediates the potentiating effect of plant polyphenols on 1,25D-induced differentiation in human AML cells.

Nrf2 Expression in CML and AML Patients' Peripheral Blood Mononuclear Cells Treated by Vitamin D, Carnosic Acid and Curcumin

The study focused on the role of two cell signaling pathways--KEAP1/ NRF2 and PI3K-which are known to be involved in adenocarcinomas.

Molecular Diagnostics

In view of liraglutide's antioxidative stress activity, we speculated that it could activate the nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1) pathway in the treatment of diabetes complicated with cerebral infarction.

Liraglutide Activates the Nrf2/HO-1 Antioxidant Pathway and Protects Brain Nerve Cells against Cerebral Ischemia in Diabetic Rats

Nrf2 is considered to be the main transcription factor of antioxidative stress [1, 2].

Prophylactic Use of Troxerutin Can Delay the Development of Diabetic Cognitive Dysfunction and Improve the Expression of Nrf2 in the Hippocampus on STZ Diabetic Rats

Nuclear factor erythroid 2-related factor 2 (Nrf2), a redox-sensitive transcription factor, is bound to the negative regulator Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm and degraded by the ubiquitin-proteasome pathway in basal condition [11].

Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats

Immunohistochemical markers for G6PDH, 6PGL, 6PGDH, and NRF2 were assessed by a semiquantitative evaluation method as follows [15]: 0: negative or weak immunostaining in <1% of the tumor; 1: focal expression in 1-10% of the tumor; 2: positive in 11%-50% of the tumor; and 3: positive in 51%-100% of the tumor.

Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer

indicated that the HER2-targeted therapeutic treatment promoted reactive oxygen species (ROS), glutathione (GSH) depletion, reduction in nuclear factor erythroid 2-related factor 2 (Nrf2) levels, and inhibition of Nrf2 function in ovarian cancer cell lines [14].

EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by Increasing ROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway