The TST was higher in the exposed group (by 10.7 min) as a result of significant increase in the total duration of REM sleep and nonsignificant trend of increase of NREM
(by 1.8 min and 8.9 min, respectively; p = 0.037 and p = 0.057).
The cyclic alternating pattern as a physiologic component of normal NREM
Participants were purposefully selected (Merriam, 2009) based on their enrollment in NREM
sleep stage 4 (NREM4): this stage is a continuation of deep sleep.
Based on findings from previous studies [4, 14, 29, 30] and after excluding sleep parameters with high correlations, REM latency and NREM
stage 4 duration were entered as independent variables to predict reduction in psychopathological scores in linear regression analysis.
This finding was also shown in a previous study where an increase in NREM
AHI was found to be associated with daytime sleepiness as assessed by MSLT .
The percentage of NREM
sleep increased from a mean of 83.6 [+ or -] 10.1% at baseline to 89.6 [+ or -] 6.8% after 6 months of LCIG infusion therapy, although differences did not reach statistical significance (P = 0.080) (Table 3).
The nonparametric Mann-Whitney test revealed a significant difference in the sleep efficiency and the percentage of stage 3 NREM
between patients with and without OSA.
Increased protein synthesis, as required for synaptic strengthening, was first found during NREM
As in each electrophysiological variable, averages were obtained every five seconds, a time series was created with 24 values, 12 of which corresponded to wakefulness (W1-W12) and 12 to S1 of NREM