NRAMP

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NRAMP

A protein of the solute carrier family 11, encoded by SLC11A1 on chromosome 2q35, which transports iron and other divalent metals (e.g., manganese, cobalt, zinc, cadmium and lead) across the apical membrane of enterocytes in the brush border of the GI mucosa and into cells by a proton-coupled process.
 
Abnormal in
Mutations of SLC11A1 have been associated with increased susceptibility to infections (e.g., tuberculosis and leprosy), and inflammatory diseases (e.g., rheumatoid arthritis and Crohn’s disease).
References in periodicals archive ?
Huang, "SLC11A1 (formerly NRAMP1) gene polymorphisms and tuberculosis susceptibility: a meta-analysis," International Journal of Tuberculosis and Lung Disease, vol.
Considering the important role of NRAMP1 gene in defending bacterial and viral infection, in this study, we investigated its mRNA expression in different tissues, identified the polymorphisms of porcine NRAMP1 gene, and then analyzed their association with some immune traits to evaluate its potential effects in four pig populations including Large White and three Chinese native breeds (Wannan Black, Huai pig, and Wei pig).
Based on the NRAMP1 gene mRNA sequence (ENSEMBLE Transcript ID: ENSSSCT00000024413), the reverse transcriptase-polymerase chain reaction (PCR) amplification method was used to detect mRNA expression of the NRAMP1 gene.
The human NRAMP1 gene has been shown to contain several polymorphic regions, including areas within intron 4 (INT4) and the 3'-untranslated region (UTR), that are apparently associated with increased susceptibility to infection by intracellular pathogens (22, 33, 34).
In the course of this investigation, we discovered a previously undescribed SNP within the 3'-UTR of the NRAMP1 gene (3'-UTR, STP+86; Fig.
Borrego et al., "Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice," Genes and Immunity, vol.
Martin, "Lack of association between NRAMP1 gene polymorphisms and Trypanosoma cruzi infection," Tissue Antigens, vol.
Further, TM4 is known to play an important role in positioning the NRAMP1 protein within the phagosomal membrane (Malo et al., 1994).
NRAMP1 genetic polymorphisms as a risk factor of tuberculous pleurisy.
Alcais and coworkers (2000) showed that NRAMP1 was linked to lepromin reaction, (45) whereas another group worked with the microsatellite of the promoter region and found that a combination between some genotypes and the lepromin negative reaction could contribute to susceptibility.
Natural resistance associated macrophage protein 1 (SLC11A1 or NRAMP1) is a membrane phosphoglycoprotein of macrophages (Cellier et al., 1996).
(35) isolated the Nramp1 (natural resistance-associated macrophage protein 1) gene as a strong candidate for the Bcg mutation based on its map location, its macrophage-restricted expression pattern and a nonconservative [Gly.sup.169] Asp substitution in the protein of all susceptible strains.