NRAMP


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NRAMP

A protein of the solute carrier family 11, encoded by SLC11A1 on chromosome 2q35, which transports iron and other divalent metals (e.g., manganese, cobalt, zinc, cadmium and lead) across the apical membrane of enterocytes in the brush border of the GI mucosa and into cells by a proton-coupled process.
 
Abnormal in
Mutations of SLC11A1 have been associated with increased susceptibility to infections (e.g., tuberculosis and leprosy), and inflammatory diseases (e.g., rheumatoid arthritis and Crohn’s disease).
References in periodicals archive ?
Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes.
Table 2 Genes of transporters isolated from various plants involved in heavy metal uptake Genes Plant Elements References OsNramp1 Rice Mn Belouchi et al., 1997 OsNramp2 Cpx-type heavy Arabidopsis Cu, Zn, Cd, Pb Tabata et al., metal ATPases 1997 Williams et al., 2000 Belouchi et al., 1997 Nramp Arabidopsis Cd, divalent Belouchi et al., metals 1997 Thomine et al., 2000 CDF family Arabidopsis Zn, Co, Mn Maser et al., proteins 1998 ZIP family Arabidopsis Van der Zaal et ZATI, ZAT2, al., 1999 ZAT3) Thlaspi Lombi et al., caeralescens 2002 Pence et al., 2000 Assuncao et al., 2001 Table 3 Phytoremediation experiments Using bacteria, AMF, and the conjugation of both microorganisms Heavy Plants Microorganisms metals Brassica juncea Azotobacter chroococum Ph.
Brown DH, Lafuse W, Zwilling BS (1995) Cytokine-mediated activation of macrophages from Mycobacterium bovis BCG-resistant and susceptible mice: differential effects of corticosterone on antimycobacterial activity and expression of the Bcg gene (candidate Nramp).
The Nramp (Bcg/Lsh/Ity) gene was originally identified among inbred strains of mice that were susceptible to infection with several different intracellular pathogens, including Mycobacterium bovis, Leishmania donovani, Salmonella typhimurium, and M.
Some of them are heavy-metal ATPases, natural resistance-associated macrophage proteins (NRAMPs), cation diffusion facilitators, the Zrt- and Irt- like proteins family, and the cation antiporters (Hall & Williams, 2003).
Several issues concerning the biochemical function of Nramp 1 with respect to intracellular survival of taxonomically unrelated pathogens remain unresolved.
Resistance to intracellular infections: comparative genomic analysis of Nramp. Trends Genet 1996;12:201-4.
Identification and characterization of a second mouse Nramp gene.
Genetic and physical mapping of 2q35 in the region of NRAMP and IL8R genes: identification of a polymorphic repeat in exon 2 of NRAMP.