NR3C1


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NR3C1

A gene on chromosome 5q31.3 that encodes a glucocorticoid receptor, which acts as either a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, or as a regulator of other transcription factors.

Molecular pathology
NR3C1 mutation are associated with generalised glucocorticoid resistance.
References in periodicals archive ?
Exposure to ELS or glucocorticoids has also been shown to lead to epigenetic alterations of genes such as CRH, NR3C1, and FKBP5.
NR3C1 promoter revealed that monozygotic [160] twins are generally more similar in their DNA methylation level than dizygotic twins BPA and phthalates Avissar-Whiting Increase miR-146a et al.
Most of the primer sequences are gathered from literature: Angptl4 rs1044250 [21], IL-13 rs848 [4], MIF rs755622 [22], nNOS rs2682826 [8], MDR1 rs1128503, rs2032582, rs1045642 [9], and NR3C1 rs41423247 [23].
Sequence variants in a total of 8 genes were associated with an increased risk for SF development: NR3C1, ANKH, VDR, ROR2, CALCR, IL6, CBG, and COL1A2 (Table 2).
(4-6) One of them was on the subject of the human glucocorticoid receptor gene (NR3C1) Bcl-1 CG polymorphism in rheumatoid arthritis (RA) patients and the other was regarding Glu298Asp, -786T>C, and Intron 4 a/b Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Behcet's Disease.
From 25 DNA methylation markers that had been examined for their methylation status in nonneoplastic gastric mucosa and in gastric cancer in a previous study,13 we selected 7 markers showing H pylori--associated hypermethylation (CALCA, CDH1, CRABP1, CYP1B1, DAPK1, GR1N2B, TW1ST1) and 5 additional markers displaying cancer-associated hypermethylation (HOXA1, NEUROG1, NR3C1, SMAD9, TUMPS).
en 2003 se observo que la presencia de un evento estresante temprano lleva a un aumento en la liberacion de glucocorticoides con disminucion en la expresion de sus receptores, al parecer por la metilacion del gen del receptor de glucocorticoide (NR3C1) [26], lo cual es semejante a la fisiopatologia del trastorno depresivo mayor [27], como se resume en la figura 1.
He revealed that people without childhood abuse history did not show the same pattern of DNA modification, and had normal expression of NR3C1, a gene linked to stress responses.
The result showed that 11 overlapping proteins (ACACA, ampC, APP, BCL2, CDK2, FASN, gyrB, katA, KCNH2, MAPK3, and NR3C1) were related to many different biological functions including oxidoreductase activity, MAP kinase activity, and NF-kappa-B binding (Figure 11(a)).
Examining the joint contribution of placental NR3C1 and HSDUB2 methylation for infant neurobehavior.
Studies have shown that epigenetic changes to the gene for the type II glucocorticoid receptor (NR3C1) are a likely mechanism explaining the neuroendocrine effects of chronic stress (for example, having a stressful childhood).