NR3C1


Also found in: Dictionary, Financial, Encyclopedia.

NR3C1

A gene on chromosome 5q31.3 that encodes a glucocorticoid receptor, which acts as either a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, or as a regulator of other transcription factors.

Molecular pathology
NR3C1 mutation are associated with generalised glucocorticoid resistance.
References in periodicals archive ?
Sequence variants in six genes were associated with decreased SF risk: NR3C1, AR, VDR, CALCR, COL1A2, and LRP4 (Table 2).
NR3C1 encodes a protein expressed in neurons that responds to hormones called glucocorticoids.
Researchers have identified functional polymorphisms in the genes encoding two receptors, NR3C1 and NR3C2, which are associated with differential responses to stress (Wust et al.