GRIN3A

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GRIN3A

A gene on chromosome 9q31.1 that encodes a subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN3A forms a complex with GRIN1, GRIN2A, -2B, -2C or -2D and PPP2CB; it may play a role in PPP2CB-NMDAR mediated signalling and in the development of dendritic spines. It is expressed in foetal brain.
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References in periodicals archive ?
Poosch, "NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A," Molecular Brain Research, vol.
Association of the small GTPase Rheb with the NMDA receptor subunit NR3A. Neurosignals 18:203-209.
El iGluR-NMDA es un complejo macromolecular multimerico, conformado por diferentes subunidades denominadas NR1, NR2A-D y NR3A y B[24].
(6) NR3A and NR3B receptor subunits are widely distributed in brain.
Tuet al., "Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons," Journal of Neurophysiology, vol.