GRIN2B

(redirected from NR3)

GRIN2B

A gene on chromosome 12p12 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2B forms a complex with GRIN1, GRIN3A and PPP2CB; it interacts with HIP1, NETO1, MAGI3 and DAPK1, and with the PDZ domains of INADL and DLG4. It is highly expressed in the fronto-parieto-temporal cortex and hippocampus pyramidal cells.

Molecular pathology
Defects in GRIN2B cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
30am, or donations in memory of Maureen to Cancer Research UK may be sent c/o Nicholas E Potts & Daughter Funeral Services, Angel House, 20 Angel Road, Norwich NR3 3HP.
Brunei Way Sweetbriar Industrial Estate Norwich Norfolk NR3 2BD
It's armed with an advanced Parrot NR3 noise reduction feature, automatically downloads your phonebook, and has a voice command feature that actually works.
16) The Grin1 and Grin2 gene expression produces different combinations of NR1 subunit with four different types of NR2 subunit (NR2A-D) and two types of NR3 (NR3 A-B), forming a multitude of NMDA receptors with different phenotypes and biophysical properties as well as different patterns of expression in the mammalian brain during development and adulthood.
T] (T > = 20) The number of positively Rooms, which correspond responded items TS2 to this value of TS2 TS2 = 0 NR4, NR5, NR6, NR7 TS2 = 1 NR1, NR2, NR3, NR10, NR13, NR14 TS2 = 2 NR8, NR9, NR11, NR12 Table 7.
Las mas comunmente encontradas formando diferentes estequiometrias en este receptor incluyen la NR1 NR2 (A-D) (7) y NR3 (A-B) (8).
Potts and Daughter Independent Funeral Services, Angel House, 20 Angel Road, Norwich, NR3 3HP by 10.
Flowers may be sent to Nicholas E Potts and Daughter Independent Funeral Services, Angel House, 20, Angel Road, Norwich, NR3 3HP, by 10.
It adopts a trigonal pyramidal structure, in which a phosphorus atom is located at one point; this structure is the same as that of amine, NR3.
Existe cierta heterogeneidad de la subunidad NR2 ya que presenta cuatro subtipos NR2A-NR2D, que poseen perfiles de expresion especificos dentro del cerebro (5,6); la subunidad NR3 presenta dos subtipos NR3A y NR3B (7,8).
Researchers have identified one type of NR1 subunit, four types of NR2 subunits, and two types of NR3 subunits.