GRIN2B

(redirected from NR3)

GRIN2B

A gene on chromosome 12p12 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2B forms a complex with GRIN1, GRIN3A and PPP2CB; it interacts with HIP1, NETO1, MAGI3 and DAPK1, and with the PDZ domains of INADL and DLG4. It is highly expressed in the fronto-parieto-temporal cortex and hippocampus pyramidal cells.

Molecular pathology
Defects in GRIN2B cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
Appraisal wells V2Y Down-dip and NR3 Down-dip were drilled for Barmer Hill Turbidite reservoirs.
It's armed with an advanced Parrot NR3 noise reduction feature, automatically downloads your phonebook, and has a voice command feature that actually works.
T] (T > = 20) The number of positively Rooms, which correspond responded items TS2 to this value of TS2 TS2 = 0 NR4, NR5, NR6, NR7 TS2 = 1 NR1, NR2, NR3, NR10, NR13, NR14 TS2 = 2 NR8, NR9, NR11, NR12 Table 7.
Flowers may be sent to Nicholas E Potts and Daughter Independent Funeral Services, Angel House, 20, Angel Road, Norwich, NR3 3HP, by 10.
Potts and Daughter Independent Funeral Services, Angel House, 20 Angel Road, Norwich, NR3 3HP by 10.
It adopts a trigonal pyramidal structure, in which a phosphorus atom is located at one point; this structure is the same as that of amine, NR3.
Researchers have identified one type of NR1 subunit, four types of NR2 subunits, and two types of NR3 subunits.
Send your entry to Career Makeover Competition, Pitman Training Scotland, c/o Plain Speaking PR, Epic, 112-116 Magdalen Street, Norwich, NR3 1JD by Thursday, August 28.
Fortunately, John Savage of Tring, Hertfordshire, has discovered publication of the UK Rail Timetable has gone to the Stationery Office and it costs pounds 15, post free, from TSO Ltd, PO Box 29, Norwich NR3 1GH, www.
Data Protection Act 1998 The Privacy and Electronic Communications Regulations 2003 Printed copies are available from TSO, PO Box 29, Norwich, NR3 1GN.
The Standard is available to order from TSO (The Stationery Office), PO Box 29, Norwich, NR3 1GN, UK, priced at 90 [pounds sterling] plus 3.
3279T>G) located in the NR3 motif is associated with a decrease in transcriptional activity, to ~62% of wild type (9).