GRIN2C

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GRIN2C

A gene on chromosome 17q25 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2C forms a complex with GRIN1, GRIN3A or GRIN3B, and interacts with PDZ domains of INADL and DLG4. It is highly expressed in the cerebellum.
References in periodicals archive ?
Specifically, this aversion-resistant drinking was associated with increased expression of NMDARs that contain the NR2C subunit at synapses where glutamatergic cells from the medial prefrontal cortex and insular cortex connect with NAc MSNs (Seif et al.
Innovative concepts of green road construction are now being developed is New Road Construction Concept (NR2C) in European infrastructure vision 2040 [3].
Clustering related characteristics produces this selected number of statements, called new road construction concepts in the context of NR2C, representing and expressing the major users and stakeholders' requirements.
Another study using NR2C knockout mice found that the NMDA NR2C subunit is required for the acquisition of conditioned fear.
Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory.
Poosch, "NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A," Molecular Brain Research, vol.
Roche, "Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/ Akt phosphorylation of NR2C," Neuron, vol.
Poosch, "NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1(Com), NR2A, NR2B, NR2C, NR2D and NR3A," Molecular Brain Research, vol.
Benke, "NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins," Journal of Neurochemistry, vol.