The Company's neurology pipeline is led by CERC-301, a Glutamate NR2B
selective, NMDA Receptor antagonist, which Cerecor is currently exploring as a novel treatment for orthostatic hypotension.
Accumulating evidence indicates that the pathophysiology of depression also involves the N-methyl-D-aspartate receptor (NMDAR), particularly subtype 2B (NR2B
It also covers methods of treating conditions responsive to NR2B
Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B
showed that expression levels for the neurotropic factors, the major subunits of the hippocampal glutamate N-methyl-D-aspartate receptor channel (NR2A and NR2B
) as well as synaptophysin were significantly decreased in response to maternal and postweaning HFD.
DAPK1 interaction with NMDA receptor NR2B
subunits mediates brain damage in stroke.
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B
AIE has been reported to increase NMDA receptor binding in the frontal cortex, as well as the expression of one subunit of this receptor (i.e., the NR2B
Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B
glutamate receptor subunits in rat forebrain.
Overexpression of N-methyl-D-aspartic acid receptor 2B (NR2B
) plays an important role in the development of hyperalgesia .
Griffante, "NMDA-induced ERK signalling is mediated by NR2B
subunit in rat cortical neurons and switches from positive to negative depending on stage of development," Neuropharmacology, vol.
Tsien, "Differential effects of enrichment on learning and memory function in NR2B
transgenic mice," Neuropharmacology, vol.