GRIN2B

(redirected from NR2B)

GRIN2B

A gene on chromosome 12p12 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2B forms a complex with GRIN1, GRIN3A and PPP2CB; it interacts with HIP1, NETO1, MAGI3 and DAPK1, and with the PDZ domains of INADL and DLG4. It is highly expressed in the fronto-parieto-temporal cortex and hippocampus pyramidal cells.

Molecular pathology
Defects in GRIN2B cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
The Company's neurology pipeline is led by CERC-301, a Glutamate NR2B selective, NMDA Receptor antagonist, which Cerecor is currently exploring as a novel treatment for orthostatic hypotension.
Accumulating evidence indicates that the pathophysiology of depression also involves the N-methyl-D-aspartate receptor (NMDAR), particularly subtype 2B (NR2B) (13).
It also covers methods of treating conditions responsive to NR2B antagonists.
Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation.
showed that expression levels for the neurotropic factors, the major subunits of the hippocampal glutamate N-methyl-D-aspartate receptor channel (NR2A and NR2B) as well as synaptophysin were significantly decreased in response to maternal and postweaning HFD.
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit.
AIE has been reported to increase NMDA receptor binding in the frontal cortex, as well as the expression of one subunit of this receptor (i.e., the NR2B subunit).
Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain.
Overexpression of N-methyl-D-aspartic acid receptor 2B (NR2B) plays an important role in the development of hyperalgesia [2].
Griffante, "NMDA-induced ERK signalling is mediated by NR2B subunit in rat cortical neurons and switches from positive to negative depending on stage of development," Neuropharmacology, vol.
Tsien, "Differential effects of enrichment on learning and memory function in NR2B transgenic mice," Neuropharmacology, vol.