GRIN2A

(redirected from NR2A)

GRIN2A

A gene on chromosome 16p13.2 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning).

Molecular pathology
Defects in GRIN2A cause epilepsy with neurodevelopmental defects; GRIN2A somatic mutations are seen in melanoma, suggesting a role for the glutamate signalling pathway in the pathogenesis of melanoma.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
showed that expression levels for the neurotropic factors, the major subunits of the hippocampal glutamate N-methyl-D-aspartate receptor channel (NR2A and NR2B) as well as synaptophysin were significantly decreased in response to maternal and postweaning HFD.
Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression.
Activation of D1 receptors results in the phosphorylation of NMDA receptors (especially the NR2A and NR2B receptor subunits) via protein phosphatase-1 and Fyn protein tyrosine kinase and consequently triggers a rapid redistribution of NMDA receptors via trafficking from synaptic to extrasynaptic compartments.[sup][76],[77] Over time, this functional link between D1 and NMDA receptors results in a change of corticostriatal synaptic plasticity, known as long-term potentiation (LTP), which could promote the development of LID.[sup][77],[78]
5 The role of a subset of anti-DNA antibodies has been suggested, that cross reacts with specific sequences present on ligand binding domain of NR2 receptors, more specifically NR2a and NR2b.
Yagita et al., "Activation of NR2A receptors induces ischemic tolerance through CREB signaling," Journal of Cerebral Blood Flow and Metabolism, vol.
Furthermore, DHA deficiency during development also resulted in marked decreases of synapsins and NMDA receptor subunit NR2A, particularly in CA3 region of hippocampus with concomitant impairment of long-term potentiation [37].
Of note, a recent study has found antibodies reactive with NMDA receptor NR2A subunit on neuronal cells (anti-NR2A) in ~20% of NPSLE patients with different types of epilepsy [11].
Interestingly, chemical kindling increases NR2A subunit mRNA in the hippocampus, [gamma]2 subunit of [GABA.sub.A] receptor mRNA in the piriform cortex (36), and [GABA.sub.B] receptor binding of whole brain (37).
Auditory stimulation with natural contact calls affects the expression of NR2A and NR2B NMDA subunit mRNAs as assessed by in situ hybridization histochemistry in the neurons of the thalamic auditory relay nucleus, the nucleus ovoidalis of a vocal learning parrot species, the budgerigar (Melopsittacus undulatus).
Peng, "Alterations of NMDA receptor subunits NR1, NR2A and NR2B mRNA expression and their relationship to apoptosis following transient forebrain ischemia," Brain Research, vol.