NR1C3 | definition of NR1C3 by Medical dictionary
PPARG (redirected from NR1C3)
PPARG A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
peroxisome proliferator-activated receptor-gamma gene,
A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive
The gene for PPAR[alpha] is NR1C1, the gene for PPAR([beta]/[delta]) is NP1C2, and the gene for PPAR[gamma] is NR1C3
- Nuclear receptor PPAR gamma-fl NR1C3
In contrast, PPAR[gamma] (NR1C3
) controls fat storage in adipose tissue by promoting differentiation and survival of adipocytes and also plays major roles in the control of insulin sensitivity (Lehrke and Lazar 2005).
The three PPAR isoforms, PPAR[alpha] (NR1C1), PPAR[beta]/[delta] (NR1C2), and PPAR[gamma] (NR1C3
), share 60% to 80% of structural homology [2, 3] and exhibit a distinct tissue expression pattern but can exert similar or different physiological functions .
Peroxisome proliferator-activated receptor [gamma] (PPAR[gamma] and NR1C3
) is a ligand-dependent nuclear receptor, which was initially established as the dominant regulator of adipocyte differentiation [1, 2].
The PPARs consist of three isoforms: PPAR[alpha] (NR1C1), PPAR[beta]/[delta] (NR1C2; NUC1; FAAR fatty acid-activated receptor), and PPAR[gamma] (NR1C3