PPARA

(redirected from NR1C1)

PPARA

A gene on chromosome 22q12-q13.1 that encodes a ligand-activated transcription factor, which is a key regulator of lipid metabolism. PPARA is a receptor for peroxisome proliferators such as hypolipidaemic
drugs and fatty acids, regulating the peroxisomal beta-oxidation pathway of fatty acids and acting as a transcription activator for ACOX1 and P450. PPARA is upregulated by heterodimerisation with RXRA and downregulated by heterodimerisation with NR2C2.
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The gene for PPAR[alpha] is NR1C1, the gene for PPAR([beta]/[delta]) is NP1C2, and the gene for PPAR[gamma] is NR1C3 [14].
PPAR[alpha] (NR1C1) is the founding member of the family and was initially isolated as the receptor inducing the hepatic proliferation of peroxisomes in rodents in response to synthetic chemicals.
The objective of present study is to examine dose-dependent and time-course effects of Pb on NMDAR (NR1C1, NR2A, and NR2B), synapsin and calcium/calmodulin kinase II (CaM KII) in primary cultured neuronal cells.
The three PPAR isoforms, PPAR[alpha] (NR1C1), PPAR[beta]/[delta] (NR1C2), and PPAR[gamma] (NR1C3), share 60% to 80% of structural homology [2, 3] and exhibit a distinct tissue expression pattern but can exert similar or different physiological functions [3].
The PPARs consist of three isoforms: PPAR[alpha] (NR1C1), PPAR[beta]/[delta] (NR1C2; NUC1; FAAR fatty acid-activated receptor), and PPAR[gamma] (NR1C3).
The PPARs are class I ligand-activated nuclear receptors (termed NR1C1 to C3 according to the unified nuclear receptor nomenclature) and are generally induced by fatty acids.
The PPAR[alpha] (NR1C1), PPAR[beta]/[delta] (NR1C2), and PPAR[gamma] (NR1C3) genes encode proteins that share a highly conserved structure and molecular mode of action, yet the array of genes regulated by each PPAR isotype is divergent and may also differ from one species to another [59].