GRIN1

(redirected from NR1)
Also found in: Acronyms.

GRIN1

A gene on chromosome 9q34.3 that encodes the zeta subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in the plasticity of synapses (central to memory and learning).

Molecular pathology
Defects in GRIN1 cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
Effects of EA at GV20-GB34 on the Phosphorylation of Hippocampal NR1 Subunits in CCI Rats.
As previously reported, NR1 phosphorylation at S897 by protein kinase A reduced the endoplasmic reticulum (ER) retention and facilitated NR1 exiting from the ER to the cell surface [29, 30], and the decreased phosphorylation of NR1 at S897 was proved to be related to multiple psychiatric disorders and cerebral diseases, including schizophrenia and NMDA-induced brain damage [31-33].
The DIG-labeled antisense probes were hybridized to NR1 mRNA in whole-mount CNS preparations, and the neurons containing the probe-target duplex were localized and visualized with alkaline phosphatase-conjugated anti-DIG antibody fragments (Boehriger Mannheim).
We report here the cloning of two putative NR1 subunits from Aplysia and Lymnaea.
Under the same molding conditions, the crystallinity at the different regions of microcellular neat resin NR1 and microcellular nanocomposites NC5 and NC7.5 are 27.1% (NR1 skin), 25.0% (NR1 core), 24.0% (NC5 skin), 23.3% (NC5 core), 21.8% (NC7.5 skin), and 20.5% (NC7.5 core), respectively.
A big difference in cell structure for neat resin NR1 and nanocomposite NC7.5 is presented in Fig.
The nr7 Toyota TS030 of Alex Wurz got a good start to move ahead of the nr2 Audi R18 ultra of Tom Kristensen at the first corner, with the Austrian then tracking the nr1 Audi R18 e-tron quattro of Andre Lotterer for the next eleven laps before taking the lead when the lead car got stuck behind some back markers.
New Delhi, June 14 -- The nr1 Audi R18 e-tron quattro continued to lead from the front in the first qualifying session of the 2012 24 Heures du Mans after setting the fastest time in the earlier Free Practice session.