22 May 2017 - Australia-based exploration and mining company NQ Minerals plc (NQMI
: NEX) has completed the acquisition of all of the issued and outstanding shares of Keen Pacific Ltd., along with its wholly-owned subsidiaries Ivy Resources Pty Ltd and Hellyer Gold Mines Pty Ltd, the company said.
Whereas increased cardiac troponin I (cTnI) (4) has likewise been shown to correlate with adverse outcomes in unstable angina and non-Q-wave myocardial infarction (NQMI), (9-14), there are several barriers to similar standardization of cTnI for application in this setting (8).
We now extend our analysis of this population with a simultaneous evaluation of the analytic and prognostic performance of three current generation cTnI assays at a decision limit equal to the 97.5th percentile for healthy controls or MDC (cTnI [greater than or equal to] 0.1 [micro]g/L) with respect to 43-day outcomes among patients with unstable angina and NQMI enrolled in TIMI 11B.
TIMI 11B was a randomized, double-blind, parallel group trial of the low-molecular weight heparin, enoxaparin, compared with unfractionated heparin for the treatment of patients presenting with unstable angina or NQMI. Participants in TIMI 11B were required to have an episode of ischemic discomfort at rest occurring within 24 h of enrollment.
In this high-risk population of patients with unstable angina or NQMI, baseline cTnI values were abnormal ([greater than or equal to] 0.1 [micro]g/L) for 368 (58%), 395 (62%), and 418 (66%) of patients with the Bayer Immuno 1, ACS:180, and Dimension RxL assays, respectively.
Final diagnoses for the presenting symptoms made by the site investigators on the basis of WHO criteria using CK/CKMB results were unstable angina for 50.7% and NQMI for 42.4%, with <7% of participants being diagnosed with Q-wave MI or noncardiac chest pain.