NPSR1

NPSR1

A gene on chromosome 7p14.3 that encodes a member of the G protein-coupled receptor 1 family which is expressed in respiratory cilia and in bronchial smooth muscle cells in asthmatics; NPSR1 may be active in signalling pathways in an autocrine or paracrine fashion.

Molecular pathology
NPSR1 mutations may play a pathogenetic role in asthma and other IgE-mediated diseases.
References in periodicals archive ?
The 33 SNPs in region B lay within the nonprotein-coding NPSR Antisense RNA1 (NPSR1-AS1) and immediately upstream of the G protein-coupled receptor coding neuropeptide S receptor 1 (NPSR1) (Figure 1(b)).
One of these genomic regions of association was within the protein kinase, CGMP-dependent, type I gene (PRKG1) whilst another was within NPSR1 antisense RNA 1 (NPSR1-AS1), which presumably has a role in posttranscriptional control of the nearby gene neuropeptide S receptor 1 (NPSR1).
NPSR1 is a G protein-coupled receptor that has been linked to asthma susceptibility [32] and inflammatory bowel disease [33].
Soderhall et al., "NPSR1 polymorphisms influence recurrent abdominal pain in children: a population-based study," Neurogastroenterology & Motility, vol.
(b) The Chr 7: 34560375-34666861 region, within the nonprotein-coding NPSR1 antisense RNA 1 (NPSR1-AS1) and immediately upstream of the G protein-coupled receptor coding neuropeptide S receptor 1 (NPSR1).
Seddighzadeh et al., "Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis," PLoS One, vol.
Low functioning Asn107 variant NPSR1 causes a disorder of the neuropeptide S (NPS) neurotransmitter system.
Schuhmacher et al., "The functional coding variant [Asn.sup.107]Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response," International Journal of Neuropsychopharmacology, vol.