WT1(redirected from NPHS4)
WT1A gene on chromosome 11p13 that encodes a transcription factor with a central role in urogenital development. WT1 displays complex tissue-specific and polymorphic imprinting pattern, with biallelic and monoallelic expression from the maternal and paternal alleles in different tissues. WT1 mRNA undergoes RNA editing, a tissue-restricted and developmentally regulated process.
WT1 is mutated in a small subset of patients with Wilm's tumours.