NPFFR2

NPFFR2

A gene on chromosome 4q21 that encodes a receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides (morphine-modulating peptides) that may function in pain modulation and regulation of the opioid system. NPFFR2 can also be activated by various naturally occurring or synthetic FMRF-amide-like ligands. It mediates its action by associating with G proteins that activate a phosphatidylinositol-calcium second messenger system.
References in periodicals archive ?
Among them, GO:0004888 dominantly contains 33 transcripts encoding signal receptors, and these receptors could be further classified into several subgroups: OXTR, LOC431251 and SSTR3 belong to reproductive hormone receptors; CHRM2, ADRA2B, P2RX4, P2RY2, EDNRB2, GABRB2, GABRG2, LOC428961 and NPFFR2 function as receptors mediating neurotransmitters or neuropeptide; GRIN2B and GRIN3A could modulate the efficiency of synaptic transmission; NTRK1 and NTRK2 belong to the receptor tyrosine kinase (RTK) family, and are involved with neurotrophin (GO:0005030--neurotrophin receptor activity; and GO:0043121--neurotrophin binding) (Table 5).