UHRF1

(redirected from NP95)

UHRF1

A gene on chromosome 19q13.3 that encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases, which binds to specific DNA sequences and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase, and plays a major role in the G1/S transition by regulating topoisomerase II-alpha and retinoblastoma gene expression; it also functions in the p53-dependent DNA damage checkpoint.
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References in periodicals archive ?
Similarly, Uhrf1 (ubiquitin-like PHD ring finger-1; also known as Np95) mainly interacts with DNMT1 to maintain DNA methylation in NSCs; the deletion of Uhrf1 in NSCs leads to increase the global DNA methylation and delayed neurodegeneration [27].
Bultmann et al., "Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells," EMBO Reports, vol.
(137,138) ZFP57/KAP1 complexes also interact with DNMTs and the hemimethylated DNA binding protein UHRF1 (also called NP95), which are essential for the maintenance of DNA methylation.
The DNMT1 activity is performed through interaction with Proliferating Cell Nuclear Antigen (PCNA) and Np95 during phase "S" of cell cycle [24, 25].