Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2
gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury.
As shown in Figure 4B, the expression levels of NOX2
, NOX4, DUOX1, and NOXA1 increased in 2-cell stage embryos treated with H2O2.
Extra virgin olive oil blunt post-prandial oxidative stress via NOX2
Fluorofenidone attenuates oxidative stress and renal fibrosis in obstructive nephropathy via blocking NOX2
(gp91phox) expression and inhibiting ERK/MAPK signaling pathway.
The researchers found that NOX2
, an enzyme usually involved in the body's response to infection, was shown to be present in acute myeloid leukemia (AML) cells - and this was found to be responsible for creating the ageing conditions.
(15) Four isoforms of the Nox enzyme (Nox1, Nox2
, Nox4, and Nox5) are typically expressed in vascular cells.
Mehta et al., "A combination antioxidant therapy to inhibit NOX2
and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury," Journal of Cerebral Blood Flow & Metabolism, pp.
, one isoform of Nox, is mainly expressed in the nervous system involved in the production of ROS as a result of the catalyzing the electron transfer from NADPH to oxygen .
The blots were incubated with antibodies against Bax, Bcl-2, cleaved caspase-3, [alpha]-SMA, [alpha]1(I) collagen, p47phox, p-p47phox, NOX2
,4-HNE and PPAR[gamma], and subsequently by horseradish peroxidase-conjugated secondary antibody.
Imrie et al., "NOX2
NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction," Diabetes, vol.
In human retinal microvascular endothelial cells, HMGB1 significantly upregulates levels of IL-1[beta] and reactive oxygen species, as well as expression of NADPH oxidase 2 (Nox2
), caspase-3, and PARP-1 .
Pastori et al., "Immediate antioxidant and antiplatelet effect of atorvastatin via inhibition of Nox2
," Circulation, vol.