NOS3


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NOS3

A gene on chromosome 7q36 that encodes endothelial nitric oxide synthase (eNOS), a small molecule implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. eNOS is a critical mediator of cardiovascular homeostasis that regulates the diameter of blood vessels and keeps vascular proliferation and apoptosis in check. It is upregulated by dynamin, porin and soluble guanylyl cyclase, and downregulated by interactions with Hsp90 and Cav-1 in the Golgi and by NOSIP and NOSTRIN at the plasma membrane. NOS3 is also a less preferred gene symbol for what is now designated as NANOS3, see there.
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While NOS3 variant is functional the ACE variant is not and may not be in such strong LD with the functional variant elsewhere in this gene as in UK Caucasians.
Of those genes, ALB and NOS3 have been previously reported as milk-related.
The lung expression of NOS1 (Figure 6B) and NOS3 (Figure 6D) was lower and that of NOS2 (Figure 6C) was higher than in mice supplemented with pequi oil and pequi extract.
Table 1: Different forms of NO synthase have been classified as follows (14) Name Genes Location Neuronal NOS NOS1 Nervous Tissue (nNOS or NOS1) Skeletal Muscle Type Ii Inducible NOS NOS2 Immune System (iNOS or NOS2) Cardiovascular System Endothelial NOS NOS3 Endothelium (eNOS or NOS3 or cNOS) Bacterial NOS multiple Various Gram(+) Species (bNOS) Name Function Neuronal NOS Cell communication (nNOS or NOS1) Inducible NOS Immune defense against (iNOS or NOS2) pathogens Endothelial NOS Vasodilation (eNOS or NOS3 or cNOS) Bacterial NOS Defense Against Oxidative (bNOS) Stress, Antibiotics, Immune Attack
La eNOS (NOS3) constitutiva fue determinada con un kit comercial adquirido de R & D systems (Minneapolis, MN, USA), siguiendo las instrucciones del fabricante.
Gene SNP Significant association to PAD Calcium NOS3 Glu298Asp No signaling pathway GBN3 C825T No Renin- ACE ACE_1/D No angiotensin system pathway AGT Met235Thr Yes (only in African Americans) Thr174Met No -6G/A No Porphyrin HMOX1 [(GT).sub.n] -length No and polymorphism chlorophyll metabolism pathway SNP=single nucleotide polymorphism; PAD=peripheral artery disease Table 3.
Associacao da Atividade Fisica e do Polimorfismo G894T da Enzima Oxido Nitrico Sintase Endotelial (NOS3) na Prevalencia de Fatores de Risco e Morbidades Cardiovasculares em Idosos.
Endothelial nitric oxide synthase (NOS3) genetic variants, maternal smoking, vitamin use, and risk of human orofacial clefts.
Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy.
Prof Tempfer said: "We found a significant difference for one variation of the NOS3 gene between the two groups."
They are the cauliflower mosaic virus 35S promoter, the EPSPS chloroplast transit protein (CTP) sequence from petunias and the 3' untranslated region of the nopaline synthetase gene (NOS3').