NOS2

(redirected from NOS2A)

NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
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One of these associations is NOS2A promoter polymorphism, which may play a role in the susceptibility to HSP and the development of nephritis.
2011), and decreased promoter methylation in NOS2A was observed in a group of steel workers after a 3-day work shift (Tarantini et al.
Seven CpG sites in three regions within the NOS2A gene were selected for DNA methylation analysis.
For the NOS2A CpG island, only the average of the percent methylation of four loci was evaluated.
One subject with an extremely high methylation value for NOS2A CpG island average was considered an outlier and removed from analyses.
The proportion of methylation at the CpG locus in NOS2A position 3 (located in a non-CpG island between exon 1 and 2) was 51%, whereas CpG island loci in NOS2A were largely unmethylated (< 2.
5] exposure Locus Association 7 day 1 month 6 month NOS2A Non-CpG island Position Difference in -0.
The difference in % DNA methylation in NOS2A non-CpG island per 5 [micro]g/[m.
5] was consistently and significantly associated with DNA methylation levels in NOS genes, primarily NOS2A and NOS3.
In that study, NOS2A DNA methylation level decreased after a 3-day shift in a steel mill; however, methylation was not associated with measured P[M.
2] Human genes: NOS1, nitric oxide synthase 1 (neuronal); NOS2A, nitric oxide synthase 2A (inducible, hepatocytes); NOS3, nitric oxide synthase 3 (endothelial cell).
Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis.