NOS2

(redirected from NOS2A)

NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
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Nogueira, "Analysis of polymorphisms in interleukin 10, NOS2A, and ESR2 genes in chronic and aggressive periodontitis," Brazilian Oral Research, vol.
Systemically transplanted CD34+ cells accelerated wound closure, which was correlated with decreased inflammatory activity at the wound bed characterized by reduced inflammatory gene expression such as, IL-1[beta], TNF-[alpha], IL-6, and NOS2A. At the same time, expression of anti-inflammatory molecule IL-10 was significantly increased indicating that CD34+ cell therapy has the potential to control the inflammation during wound healing process.
Anti-NOS2A shares high antisense homology (approximately 80%) to the corresponding regions of NOS2A gene.
Three genes encode NOS enzymes: NOS1 on chromosome (chr) 12 encodes neuronal NOS (nNOS), NOS2A on chr 17 encodes inducible NOS (iNOS), and NOS3 on chr 5 encodes endothelial NOS (eNOS).
Altogether eight SNPs from NOS1 and NOS2A were selected: NOS1 rs2682826 and rs1047735 and NOS2A rs1060826 based on previous PD research (Hague et al.
Interactions between NOS2A SNPs rs231480, rs2248814, and rs1060826 and smoking were also found (range of p = 0.013-0.024) [63].
One of these associations is NOS2A promoter polymorphism, which may play a role in the susceptibility to HSP and the development of nephritis.
The researchers found that variants of two genes were associated with increased risk of kidney cancer: nitric oxide synthase 2A (NOS2A), which increases levels of nitric oxide, a chemical that promotes free radical damage to cells; and prostaglandin-endoperoxide 2 (PTGS2), which produces prostaglandins, compounds that cause inflammation.
This region contains many genes involved in immune regulation, such as NOS2A and CCL2 (MCP-1), but none of these regions has been depicted with greater resolution and there is no confirmation of the association of these genes with leprosy.
NO is synthesized by 3 isoforms of NO synthase encoded by 3 distinct genes: nitric oxide synthase 1 (NOS1), (2) nitric oxide synthase 2A (NOS2A), and nitric oxide synthase 3 (NOS3).
RESULTS: A 5-[micro]g/[m.sup.3] increase in P[M.sub.2.5] was associated with a 0.20% [95% confidence interval (CI): -0.32, -0.07] to 1.0% (95% CI: -1.61, -0.56) lower DNA methylation at NOS2A position 1, 0.06% (95% CI: -0.18, 0.06) to 0.58% (95% CI: -1.13, -0.02) lower methylation at position 2, and 0.34% (95% CI: -0.57, -0.11) to 0.89% (95% CI: -1.57, -0.21) lower methylation at position 3, depending on the length of exposure and CpG locus.
Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis.