NOS2

(redirected from NOS2A)

NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
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Three genes encode NOS enzymes: NOS1 on chromosome (chr) 12 encodes neuronal NOS (nNOS), NOS2A on chr 17 encodes inducible NOS (iNOS), and NOS3 on chr 5 encodes endothelial NOS (eNOS).
Altogether eight SNPs from NOS1 and NOS2A were selected: NOS1 rs2682826 and rs1047735 and NOS2A rs1060826 based on previous PD research (Hague et al.
NOS1 SNPs rs1047735, rs2682826, and rs3741475 and NOS2A SNPs rs1060826, rs2297518, and rs3730013 genotyping was conducted at Stanford Human Genome Center; PCR (polymerase chain reaction) assays were conducted with TaqMan Universal Master Mix (Applied Biosystems), primers and probes were designed based on the NCBI (National Center for Biotechnology Information) DNA sequence and purchased from ABI (Applied Biosystems).
To safeguard against systematic genotype errors due to using different genotyping centers for fill-in genotyping of NOS1 SNPs rs1047735 and rs2682826, and NOS2A SNPs rs1060826, rs2297518, and rs3730013, 97 participants were included in both genotyping experiments; they provided an interlaboratory genotype call rate concordance of 99.
Interactions between NOS2A SNPs rs231480, rs2248814, and rs1060826 and smoking were also found (range of p = 0.
One of these associations is NOS2A promoter polymorphism, which may play a role in the susceptibility to HSP and the development of nephritis.
This region contains many genes involved in immune regulation, such as NOS2A and CCL2 (MCP-1), but none of these regions has been depicted with greater resolution and there is no confirmation of the association of these genes with leprosy.
2] Human genes: NOS1, nitric oxide synthase 1 (neuronal); NOS2A, nitric oxide synthase 2A (inducible, hepatocytes); NOS3, nitric oxide synthase 3 (endothelial cell).
2011), and decreased promoter methylation in NOS2A was observed in a group of steel workers after a 3-day work shift (Tarantini et al.
Seven CpG sites in three regions within the NOS2A gene were selected for DNA methylation analysis.
For the NOS2A CpG island, only the average of the percent methylation of four loci was evaluated.
Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis.