NOS2


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NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
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[alpha]-PD-L1 treatment also greatly increased the percent population of monocytes/macrophages (Figure 3(c): [TF.sub.(-[alpha]-PD-L1)] = 4.92 [+ or -] 1.29%; [TF.sub.(+[alpha]-PD_L1)] = 12.8 [+ or -] 2.92%, p = 0.0016) and decreased the percentage of macrophages expressing Tgm2 (Figure 3(d): [TF.sub.(-[alpha]PD-L1)] = 18.58 [+ or -] 5.69%; [TF.sub.(+[alpha]PD-L1]) = 2.1 [+ or -] 2.17%, p = 0.0034), Cxcl9 (Figure 3(e): [TF.sub.(-[alpha]PD-L1)] = [TF.sub.(+[alpha]PD-L1)] = 1.52 [+ or -] 1.24%, p = 0.002), and Nos2 (Figure 3(f): [TF.sub.(-[alpha]PD-L1)] = 97.99 [+ or -] 1.62%; [TF.sub.(+[alpha]PD-L1)] = 50.89 [+ or -] 18.07%, p = 0.00086), essentially normalizing the M1/M2 macrophage polarization distribution back to SH status.
(c, d) RT-PCR results showed that there is no difference in Nos2 and Ido1 between T + M-hPDLSCs and T + G-hPDLSCs.
Order Scale Numerical Numerical Order Scale Diagnosis Set NOS1 NOS2 NOS3 VB 1 1 1 1 L.VB GE.1 1 1.5 1.25 M.B LE.2 2 1.5 1.75 B 2 2 2 2 L.B GE.2 2 2.5 2.25 M.AV LE.3 3 2.5 2.75 AV 3 3 3 3 A.AV GE.3 3 3.5 3.25 M.G LE.4 4 3.5 3.75 G 4 4 4 4 L.G GE.4 4 4.5 4.25 M.VG LE.5 5 4.5 4.75 VG 5 5 5 5 Source: own elaboration.
For the mRNAs, in comparison with the control group, the expression level of COL19A1, NOS2, C13orf15, FOS, SPINT1, and PLAC8 was upregulated to 10.331-, 31.374-, 7.534-, 12.573-, 24.758-, and 19.885-fold in BoNTA (5 U 24 h) treated groups, respectively (Figure 3), and the expression level of FCN2, BIRC5, and E2F1 was downregulated to 1.890-, 0.923-, 0.709-fold separately (Figure 3).
Cytokines such as TNF-[alpha] and IL-[beta] may also induce NO formation by nitric oxide synthase 2 (NOS2), which has important contribution to tissue damage, oxidative stress and DNA damage when there is exacerbated secretion in the inflammatory focus (LeGrand et al.
Anabolic-androgenic steroids induce apoptosis and NOS2 (nitric-oxide synthase 2) in adult rat Leydig cells following in vivo exposure.
Three different NOS types are available: neuronal (nNOS or NOS1), inducible (iNOS or NOS2) and endothelial (eNOS or NOS3).
In this preliminary study, we have also noticed higher level of p38 MAPK phosphorylation, which could increase TNF-[alpha] production (45) and in turn induces NOS2 expression and subsequent NO generation.
The researchers screened the two best classifier genes, NOS2 and CCL27, among a different group of patients, 16 with psoriasis and 18 with eczema.
These aspects were labeled as following NOS1 tentativeness, NOS2 empirical basis, NOS3 subjectivity, NOS4 creativity, NOS5 socio-cultural embeddedness, NOS6 observations and inference, and NOS7 Laws and theories.
* NOS2 is an inducible, calcium-independent isoform, also called (iNOS).