They found that both paroxetine and the NOS inhibitor
L-NAME inhibited relaxation of penile tissue.
In a study of nine heart transplant recipients, bradycardia was observed with the NOS inhibitor
, whereas the NO donor SNP caused dose-dependent tachycardia (24).
Since NOS isoforms are present in Leydig cells, we assumed that L-NAME, a non-selective NOS inhibitor
, would block NO synthesis and, consequently, a possible basal nitrergic inhibition of purinergic currents.
Cells were subjected to the following treatments during SI: (1) untreated control; (2) SNAP ([10.sup.-7], [10.sup.-6], and [10.sup.-5] M) (Sigma); (3) brain type natriuretic peptide-32 (BNP, [10.sup.-9], [10.sup.-8], and [10.sup.-7] M) (American Peptides); (4) NOS inhibitor
N-nitro-L-arginine (L-NNA, [10.sup.-5] M) (Sigma).
Treatment with the NOS inhibitor
, [N.sup.[omega]]-nitro-L-arginine methyl ester hydrochloride (L-NAME), has been shown to prevent the chronic functional overload-induced increase in Type I MHC and the decrease in Type IIB MHC in rat plantaris muscle (Smith et al., 2002).
The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor
(L-NAME), which indicates the involvement of PGE2 and NOS in ECD induced ulcer healing activity.
Each group received different combinations of the following drugs: bilberry extract, fluoxetine (Prozac), L-arginine and L-NAME which is an NOS inhibitor
. Each group excluding the control group was subjected to stress for 21 days.
repeated the procedure using a NOS inhibitor
. As a result, the authors
On day 3, the same individuals were intravenously infused with [N.sup.G]-monomethyl-L-arginine acetate (L-NMMA), an NOS inhibitor
, at 8 AM, and again consumed anthocyanin capsules 30 min later.
Although, studies using [Nk.sup.[omega]]-nitro-Larginine methyl ester (L-NAME), an NOS inhibitor
to inhibit endogenous and exogenous NO production demonstrated that NO is essential for optimal meiotic maturation both in vitro and in vivo (Jablonka-Shariff et al., 1999).
The effects of testosterone were also tested in the presence of NOS inhibitor
N[omega]-nitro-L-arginine methyl ester (L-NAME, [10.sup.-4]M), and L-arginine (1(HM).
NO can imitate some cytokinin effects; NO donors induced betalaine accumulation in Amaranthus seedlings and NOS inhibitor
inhibited cytokinin-induced betalaine accumulation (Scherer & Holk, 2000).