NOP2

A gene on chromosome 12p13 that encodes a protein which may play a role in regulating the cell cycle and increasing nucleolar activity seen in cell proliferation. NOP2 may act as ribosomal RNA methyltransferase.

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The authors confirmed that regulating the lncRNA-hPVT1/NOP2 pathway may be a therapeutic target in treating HCC given that lncRNA-hPVT1 was shown to promote cell proliferation, cell cycling, and stem cell-like properties in HCC cells by stabilizing the NOP2 protein [32].

Wang et al., "Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2," Hepatology, vol.

Long Noncoding RNAs Act as Novel Biomarkers for Hepatocellular Carcinoma: Progress and Prospects

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