NOD2


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NOD2

A gene on chromosome 16q21 of the Nod1/Apaf-1 family that encodes a protein with two caspase recruitment (CARD) domains, which is expressed on white cells in the peripheral blood and activates NFKB protein in response to intracellular bacterial lipopolysaccharides. NOD2 mutations are linked to Crohn’s disease and Blau syndrome.
References in periodicals archive ?
SB 9200 is a small orally bioavailable dinucleotide that selectively activates within infected cells the cellular viral sensors RIG-I and NOD2 to inhibit viral replication and cause the induction of intracellular interferon signaling pathways for antiviral defense.
NOD2 activation induces muscle cell-autonomous innate immune responses and insulin resistance.
difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition.
Mutations in NOD2 were found in patients with Crohn's disease, Blau syndrome and in rabbit with NSDD (Hugot et al.
Molecular Biology schemes: Factor V-Leiden, prothrombin, MTHFR, PAII (SERPINE1), factor XIII (F13A1), GPIIIa (1TGB3), [3Fib (FGB), VKORC1, Factor XII (F12), a1 PI, APOE, APOB, ACE, CETP, TPMT, CYP2C19, CYP2D6, CYP2C8, CYP2C9, UGT1A1 , DPD (DPYD), BCHE, ALDOB, HFE, LCT, NOD2, ATP7B, FSAP (HABP2), ITGA2, KRAS.
The intervention was communication of risk assessment for Crohn's disease by postal booklet based on family history of the disease and smoking status alone, or with additional DNA analysis for the NOD2 genotype.
NOD2 is an intracellular sensor of a component of peptidoglycan in the cell wall of bacteria.
The vitamin also affects the NOD2 gene, which informs cells of the presence of invading microorganisms.
The first susceptibility gene identified for Crohn disease was NOD2 (nucleotide-binding oligomerization domain containing 2; alias, CARD15), which is involved in the innate immune response directed against components of the bacterial cell wall (3, 4).
RIG-1 and NOD2 are cytosolic viral sensors that are important for the regulation of the innate immune response and activation of intracellular interferon (IFN) signaling pathways in response to viral RNA.
NOD1 recognises peptidoglycans mainly produced by gram-negative bacteria, while NOD2 generally recognises those produced by all bacteria.
The researchers found that a protein called NOD2 triggers a cell-signaling molecule called interleukin-32 that induces general immune cells called monocytes to become specialized information-carrying dendritic cells.