NOD2


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NOD2

A gene on chromosome 16q21 of the Nod1/Apaf-1 family that encodes a protein with two caspase recruitment (CARD) domains, which is expressed on white cells in the peripheral blood and activates NFKB protein in response to intracellular bacterial lipopolysaccharides. NOD2 mutations are linked to Crohn’s disease and Blau syndrome.
References in periodicals archive ?
Sieling et al., "NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy," Nature Medicine, vol.
Nucleotide-binding oligomerization domain containing 2 (NOD2), a member of the NOD-like receptor family, has been found to be one of the critical components
Girardin, "Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1[beta] generation," Clinical & Experimental Immunology, vol.
Although they share most of the disease-causing genes, genes like ATG16L1, PTGER4, IRGM, and NOD2 have been proven to be specifically related to Crohn's disease but independent with ulcerative colitis [18, 21-23].
Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge.
Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome.
NOD1 reconoce basicamente peptidoglicanos como el acido y-D-giutamii-meso diaminopimelico (iE-DAP), presente en bacterias gramnegativas, y NOD2 reconoce el muramildipeptido (MDP), comun en bacterias grampositivas y gramnegativas (21,22).
[30] reported that ghrelin inhibited NF-[kappa]B activation, reduced TNF-[alpha] and IL-6 concentrations in lung of septic rats, and inhibited nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1).
La estimulacion de NOD2 con MDP (muramyl dipeptide) induce la formacion de autofagosomas y promueve la presentacion antigenica sobre moleculas del MHC clase II en celulas dendriticas humanas (21).
While the loss of NOD2 increases the risk of developing Crohn's disease, increased activity of this gene is also thought to exacerbate symptoms.
This encodes for a product (NOD2 or CARD15), the CD variant of which is associated with increased intestinal permeability in both CD patients and their unaffected relatives.
Crohn's disease, mycobacteria, and NOD2. Lancet Infect Dis 2004; 4: 136-137.