NOAEL


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Related to NOAEL: LOAEL

level

 [lev´el]
relative position, rank, or concentration.
l's of care the six divisions of the health care system: preventive care, primary care, secondary or acute care, tertiary care, restorative care, and continuing care.
background level the usual intensity of a chemical or other stimulus in the environment.
confidence level the probability that a confidence interval does not contain the population parameter.
l's of consciousness see levels of consciousness.
lowest observed adverse effect level (LOAEL) (lowest observed effect level (LOEL)) in studies of the toxicity of chemicals, the lowest dosage level at which chronic exposure to the substance shows adverse effects; usually calculated for laboratory animals.
no observed adverse effect level (NOAEL) (no observed effect level (NOEL)) in studies of the toxicity of chemicals, the highest dosage level at which chronic exposure to the substance shows no adverse effects; usually calculated for laboratory animals.
level of significance a statistical measure that serves as the cutoff point used to determine whether a null hypothesis is retained or rejected; the probability of incorrectly rejecting the null hypothesis (see Type I error).
sterility assurance level (SAL) the probability that a process makes something sterile (see sterilization). An SAL of 10−6 is the recommended probability of survival for organisms on a sterilized device. This level means that there is less than or equal to one chance in a million that an item remains contaminated or nonsterile.

no observed adverse effect level

,

NOAEL

The greatest known concentration of a substance that, after testing, has failed to harm plants or animals.

NOAEL,

n ‘no-observed-adverse-effect-level,’ the maximum concentration of a substance that is found to have no adverse effects upon the test subject.
References in periodicals archive ?
Most NOAEL probably represent false-positive findings anyway because of the multiple-testing fallacy.
None of the reported blood mercury levels were at or near the NOAELs from the Seychelles (Davidson et al.
Sperm count (concentration), linearity (LIN), and wobble (WOB) were significantly affected by both NOAEL and LOAEL doses of BPA.
015 ppb was calculated from the NOAEL of 25 ppb (adjusted from 25 ppb under discontinuous experimental exposure to 8 ppb under postulated continuous exposure) and uncertainty factors of 3X for interspecies extrapolation, 10X for intraspecies sensitivity, and 10X for database deficiencies.
a) NOAEL (mg/kg/day) for diethyl phthalate = 1,735; methyl paraben = 1,050; triclosan = 50.
Deriving a data-based interspecies assessment factor using the NOAEL and the benchmark dose approach.
Rusyn says a POD derived through BMD modeling can fall to right or left of the NOAEL POD, depending on the data.
In the original human health assessment, all of these end points were used to select a single NOAEL and derive an RfD.
Specifically, we derived ADIs based on the following no observed adverse effect levels (NOAELs) or lowest observed adverse effect levels (LOAELs) and uncertainty factors (UF) used to determine PHGs: Al NOAEL/LOAEL = 125 mg/day and UF = 100 (10 for duration of study, 10 for interindividual variation and sensitive subgroups) (Cal/EPA 2001a); Cd NOAEL = 19 [micro]g/day and UF = 50 (5 for protecting sensitive individuals, 10 for cancer risk due to oral exposure to Cd) (Cal/EPA 2006); Cu NOAEL = 426 [micro]g/kg-day and UF = 3 for uncertainties in study data (Cal/EPA 2008b); Ni NOAEL = 1.
These intakes are, respectively, about 50-fold lower, 5-fold lower, and 2-fold higher than the established mouse NOAEL of 25 [micro]g/kg/day (Vos et al.
The NOAEL for acute maternal and developmental toxicity of TFZ in rodents is 10 mg/kg/day, whereas the NOAEL for chronic exposure in the two-generation reproduction study in rats is 3.
In addition, we compared human exposure guidelines [generally referred to as reference doses (RfDs) in our article] resulting from using the SNCD, the BMD, and the NOAEL as PODs.