ETR was considered for inclusion in the regimen in addition to RAL if the genotype indicated low-level or higher resistance to DRV/r, no active NRTIs were available and the ETR MS was <30, particularly if there was no known previous exposure to NNRTIs
The most common mutations are associated with NNRTIs
, lamivudine and thymidine analogues, with the lamivudine-associated mutation, M184V, occurring frequently.
We also found that 3 of the 13 HIV-infected infants with drug-resistant mutations against NNRTIs
were born to mothers who did not have a resistant strain of HIV These three infants likely developed resistance because of the infant prophylaxis they received with nevirapine.
include tenofovir and adefovir dipivoxil (Hepsera[R]).
Since Sennosides A and B were identified as novel dual functions RTIs, we wanted to compare them to known NNRTIs
or RNase H inhibitors by using a series of previously described HIV-1 RT mutants.
7% (13) had NNRTIs
included in the treatment regimen and 13.
28] The NNRTIs
are also associated with transaminitis and hepatotoxicity.
Several reasons may explain these findings: first, NRTIs and NNRTIs
are seldom reported to induce side-effects that lead to metabolic-related factors of atherosclerosis, such as hyperglycemia, insulin resistance, dyslipidemia, and fat redistribution.
All PIs and NNRTIs
are metabolised by the CYP system and possess enzyme-inhibiting or enzyme-inducing properties.
The drugs belonging to the class of NNRTIs
used were 600 mg efavirenz (EFZ) and 200mg nevirapine (NVP).
The differential metabolic effects of the NNRTIs
, NRTIs and PIs are depicted in Fig.
It reduces the serum concentration of PIs and NNRTIs