NNRTIs

NNRTIs

Abbreviation for nonnucleoside reverse transcriptase inhibitors.
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ETR was considered for inclusion in the regimen in addition to RAL if the genotype indicated low-level or higher resistance to DRV/r, no active NRTIs were available and the ETR MS was <30, particularly if there was no known previous exposure to NNRTIs.
The most common mutations are associated with NNRTIs, lamivudine and thymidine analogues, with the lamivudine-associated mutation, M184V, occurring frequently.
We also found that 3 of the 13 HIV-infected infants with drug-resistant mutations against NNRTIs were born to mothers who did not have a resistant strain of HIV These three infants likely developed resistance because of the infant prophylaxis they received with nevirapine.
NNRTIs include tenofovir and adefovir dipivoxil (Hepsera[R]).
Since Sennosides A and B were identified as novel dual functions RTIs, we wanted to compare them to known NNRTIs or RNase H inhibitors by using a series of previously described HIV-1 RT mutants.
7% (13) had NNRTIs included in the treatment regimen and 13.
28] The NNRTIs are also associated with transaminitis and hepatotoxicity.
Several reasons may explain these findings: first, NRTIs and NNRTIs are seldom reported to induce side-effects that lead to metabolic-related factors of atherosclerosis, such as hyperglycemia, insulin resistance, dyslipidemia, and fat redistribution.
All PIs and NNRTIs are metabolised by the CYP system and possess enzyme-inhibiting or enzyme-inducing properties.
The drugs belonging to the class of NNRTIs used were 600 mg efavirenz (EFZ) and 200mg nevirapine (NVP).
The differential metabolic effects of the NNRTIs, NRTIs and PIs are depicted in Fig.