NNRTI


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NNRTI

abbr.
non-nucleoside reverse transcriptase inhibitor

NNRTI

NNRTI

Non-nucleoside reverse transcriptase inhibitor, see there.

NNRTI

Nonnucleoside analog reverse transcriptase inhibitor.
References in periodicals archive ?
0) (n=24) DRV-r = darunavir-ritonavir; RAL = raltegravir; ETR = etravirine; ART = antiretroviral therapy; SA = South Africa; IQR = interquartile range; ARVs = antiretroviral; NRTI = nucleoside reverse transcriptase inhibitor; NNRTI = non-nucleoside reverse transcriptase inhibitor; PI = protease inhibitor; ERC = expert review committee.
Notwithstanding our small and non-probabilistic sample, the results indicate that a NNRTI based regimen without prior resistance testing is not ideal for acutely/recently HIV-infected individuals in our setting.
In the event of needing to stop NRTIs, the whole regimen should be stopped and the NNRTI tail covered by a week of lopinavir/r (standard dose).
Numerous adult studies and one paediatric study have demonstrated the feasibility of switching from a PI to an NNRTI once VLs are <50 copies/ml.
GSS calculation was done considering all possible combinations of: NRTI [+ or -] NRTI [+ or -] NNRTI [+ or -] PI/r [+ or -] T20 [+ or -] RAL.
Researchers randomly selected 229 people starting a first-line antiretroviral combination based on a PI, an NNRTI, or the integrase inhibitor Isentress at the Albany Medical Center HIV clinic.
KIPyV WUPyV HAART 1 + - None 2 + - None 3 + - None 4 + - NRTI: FTC, TDF; PI: ATV, RTV 5 - + NNRTI: EFV; NRTI: 3TC, TDF 6 - + NNRTI: NVP; NRTI: 3TC, AZT 7 - + NRTI: 3TC, AZT; PI: ATV, RTV 8 - + NNRTI: NVP; NRTI: ABC, TDF 9 - + None 10 - + NNRTI: EFV; NRTI: 3TC, D4T 11 - + None * KIPyV, KI polyomavirus; WUPyV, WU polyomavirus; HAART, highly active antiretroviral therapy; NRTI, nucleoside reverse transcriptase inhibitor; FTC, emtricitabine; TDF, tenofovir; PI, protease inhibitor; ATV, atazanavir; RTV, ritonavir; NNRTI, nonnucleoside reverse transcriptase inhibitor; EFV, Efavirenz; 3TC, lamivudine; NVP, nevirapine; AZT, azidothymidine; ABC, D4T, stavudine.
Multivariate analysis that adjusted for NNRTI agent, baseline viral load and weight showed no effect of dose on viral suppression.
The genetic barrier of this first-generation NNRTI is low, with resistance occurring rapidly and completely after a single mutation.
Rilpivirine (Tibotec) is an NNRTI and a di-aryl-pyrimidine (DAPY).
As an example, a NNRTI-based regimen discontinuation is to be made in separate times, with NRTIs carried on for 7 days after the NNRTI discontinuation.