In the schizophrenia studies, rates of discontinuation because of an adverse event were not higher for active medication vs placebo, suggesting excellent overall tolerability, and for bipolar disorder the NNH
vs placebo on discontinuation because of an adverse event was 20, representing reasonable overall tolerability for this indication as well (Table l, (1) page 27).
Algorithm 3 Nearest-Neighbor Heuristic 1: CALCUALTE the Cost matrix [C.sub.ij] of all customers using equations (5), (6), (7), (8) 2: SORT the Cost matrix in ascending order 3: SORT the customer-list in ascending order of distances from depot to pick-up point 4: INITIALIZE a list of routes with each route serving one customer 5: for all customers c in the customer-list do 6: SELECT customer / 7: if / has not been served then 8: while routes can be merged do 9: SELECT a customer j that results in lowest cost when i 10: if / can be feasibly merged with j then 11: MERGE the routes 12: UPDATE /' to j 13: MARK i and j served 14: else 15: SELECT another j 16: end if 17: end while 18: end if 19: end for NNH
for DARP is given in algorithm 3.
Ideally you want the NNH
to be high and the NNT to be low so the NNT/NNH is small and preferably less than 1.
of 158 for patients on antidepressant therapy seen in this study is probably not clinically meaningful in that it approaches the background mortality risk in this elderly, sick population, he added.
* Latuda at all doses caused akathisia (restlessness, NNH
For patients with no previous ulcer drug use or hospitalization, the NNH
per year with SSRI use was 411.
One of the most inventive recent examples of this difficult balancing act was Erick van Egeraat's audacious remodelling of an eclectic nineteenth-century Austro-Hungarian palazzo for the ING and NNH
As a generalization, however, the numbers needed to harm (NNH
) were more than 100-fold greater than the NNTs for all three TNF antagonists.
By using the odds ratio from the meta-analysis, the investigators calculated the number needed to harm (NNH
) according to varying risk factors such as ulcer drug use and hospitalization for any upper GI event.
Number needed to treat (NNT) and number needed to harm (NNH
)--two tools of evidence-based medicine (EBM, Box 1 (1,2))--can help answer these questions.
Risk of gastrointestinal (GI) bleeding was found to be a number needed to harm (NNH
) of 108 over 10 years (RR=1.37; 95% CI, 1.15-1.62) whereas risk of hemorrhagic stroke didn't reach statistical significance (RR=1.32; 95% CI, 1.00-1.74).