NMUR2

(redirected from NMU2R)

NMUR2

A gene on chromosome 5q33.1 that encodes a neuromedin U (NMU) receptor of the Gq/11-protein-coupled receptor family, which is expressed in the CNS—especially in the substantia nigra, medulla oblongata and pontine reticular formation. NMU receptors mediate various biological effects, including uterine contraction, vasoconstriction and activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in decreased food intake via the corticotropin releasing hormone (CRH) system.
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References in periodicals archive ?
Neuromedin S (NMS), a 36 amino acid peptide structurally related to neuromedin U, identified in rat brain as ligand for the G protein-coupled receptor FM4/TGR-1, also termed neuromedin U receptor type-2 (NMU2R).
(2006) has reported stimulatory effect on HPG axis in rodents and similarly the actions of NMU, which operates through the same NMU2R centrally, having opposite role to NMS on LH release had inhibitory effect in ovariectomized female rats (Quan et al., 2003, 2004).
However, considering that NMS is able to modulate neuropeptide expression at the ARC (Ida et al., 2005), which is a major center for the integrated control of energy balance and reproduction with abundant expression of NMU2R; it is plausible that the central mechanism, whereby NMS stimulating testosterone secretion, involves the activation of ARC pathways.