GRIN2B

(redirected from NMDAR2B)

GRIN2B

A gene on chromosome 12p12 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN2B forms a complex with GRIN1, GRIN3A and PPP2CB; it interacts with HIP1, NETO1, MAGI3 and DAPK1, and with the PDZ domains of INADL and DLG4. It is highly expressed in the fronto-parieto-temporal cortex and hippocampus pyramidal cells.

Molecular pathology
Defects in GRIN2B cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
15% Tween-20 for 2 h, then incubated over night at 4 [degrees]C with primary antibodies: NMDAR2B, 1:100 from Abcam, p44/42 MAPK (Erkl /2) (137F5) 1:500; phosphorylation of ERK (pERK)(Thr202/yr204), 1:500; CREB (48H2) 1:500; Phospho-CREB (Ser133) (87G3) 1:500, from Cell Signaling Technology (Danvers, MA, USA); the membranes were washed with PBS-Tween and then incubated with a peroxidase-conjugated secondary antibody (1:2000; ZSGB-B10) at 37 [degrees]C for 3h.
Different trends in modulation of NMDAR1 and NMDAR2B gene expression in cultured cortical and hippocampal neurons after lead exposure.