GRIN2A

(redirected from NMDAR2A)

GRIN2A

A gene on chromosome 16p13.2 that encodes an epsilon subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning).

Molecular pathology
Defects in GRIN2A cause epilepsy with neurodevelopmental defects; GRIN2A somatic mutations are seen in melanoma, suggesting a role for the glutamate signalling pathway in the pathogenesis of melanoma.
References in periodicals archive ?
Postsynaptically, the neuroprotective characteristics of NO curb the excessive NMDAR-induced calcium influx and excitotoxicity by causing S-nitrosylation of the antiglutamate receptor NMDAR2A (NR2A) subunit (Figure 2).
CO has a role in NMDA-induced calcium ion ([Ca.sup.2+]) influx or excitotoxicity via S-nitrosylation of antiglutamate receptor NMDAR2A (NR2A) subunit and restores synaptic function in AD and SCZ.