NMDAR1 | definition of NMDAR1 by Medical dictionary
GRIN1 (redirected from NMDAR1)
Also found in: Acronyms
GRIN1 A gene on chromosome 9q34.3 that encodes the zeta subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in the plasticity of synapses (central to memory and learning).
Defects in GRIN1 cause mental retardation autosomal dominant type 8.
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References in periodicals archive
Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1
receptor gene in schizophrenic patients.
Cloning and localization of exon 5-containing isoforms of the NMDAR1
subunit in human and rat brains.
Induced expression of NMDAR2 proteins and differential expression of NMDAR1
splice variants in dysplastic neurons of human epileptic neocortex.
Hayashi, "NMDA (NMDAR1
) and AMPA-type (GluR2/3) receptor subunits are expressed in the inner ear," Neuroreport, vol.
Different trends in modulation of NMDAR1
and NMDAR2B gene expression in cultured cortical and hippocampal neurons after lead exposure.
Moreover, the level of NMDAR1
protein expression on RVLM in the ION-CCI group was higher than that in the sham group (Figure 4(b)).