GRIN1

(redirected from NMDAR1)
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GRIN1

A gene on chromosome 9q34.3 that encodes the zeta subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in the plasticity of synapses (central to memory and learning).

Molecular pathology
Defects in GRIN1 cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1 receptor gene in schizophrenic patients.
Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains.
Induced expression of NMDAR2 proteins and differential expression of NMDAR1 splice variants in dysplastic neurons of human epileptic neocortex.
Hayashi, "NMDA (NMDAR1) and AMPA-type (GluR2/3) receptor subunits are expressed in the inner ear," Neuroreport, vol.
Different trends in modulation of NMDAR1 and NMDAR2B gene expression in cultured cortical and hippocampal neurons after lead exposure.
Moreover, the level of NMDAR1 protein expression on RVLM in the ION-CCI group was higher than that in the sham group (Figure 4(b)).