GRIN1

(redirected from NMDAR1)
Also found in: Acronyms.

GRIN1

A gene on chromosome 9q34.3 that encodes the zeta subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in the plasticity of synapses (central to memory and learning).

Molecular pathology
Defects in GRIN1 cause mental retardation autosomal dominant type 8.
References in periodicals archive ?
Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains.
Los receptores de NMDA se componen de subunidades proteinicas NMDAR1 y NMDA2A-D.