GRIN3A

(redirected from NMDAR-L)

GRIN3A

A gene on chromosome 9q31.1 that encodes a subunit of N-methyl-D-aspartate (NMDA) receptors, which belong to the glutamate receptor channel superfamily. NMDA receptors consist of multiple subunits arranged to form a ligand-gated ion channel, which play a key role in long-term potentiation and the plasticity of synapses (central to memory and learning). GRIN3A forms a complex with GRIN1, GRIN2A, -2B, -2C or -2D and PPP2CB; it may play a role in PPP2CB-NMDAR mediated signalling and in the development of dendritic spines. It is expressed in foetal brain.
Mentioned in ?
References in periodicals archive ?
Since its discovery in 1995 by two independent groups [15, 16], GluN3A (then termed Chi-1 and NMDAR-L) has sparked great interest due to its particular properties within the NMDAR family.
Chi et al., "Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain," Journal of Neuroscience, vol.