ketamine hydrochloride(redirected from NMDA-receptor antagonists)
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a nonbarbiturate general anesthetic induction agent administered parenterally to achieve dissociative anesthesia. Ketamine hydrochloride does not cause muscle relaxation. It is a potent somatic analgesic and is particularly useful for brief, minor surgical procedures. Hallucinations, confusion, and disorientation may occur on emergence from anesthesia. See also dissociative anesthesia.
Pharmacologic effects Dissociative anaesthesia, CNS stimulant, hallucinations, visual distortion, a loss of senses, sense of time, and identity for 30 minutes to 2 hours, delirium, amnesia, impaired motor function, hypertension, depression, recurrent flashbacks, potentially fatal respiratory problems
ketamine hydrochlorideN -methyl-d-aspartate (NMDA)-receptor antagonist used to reduce intraoperative pain; contraindicated in hypertensive patients
a nonbarbiturate anesthetic related to phencyclidine (PCP), which is administered intravenously or intramuscularly to produce dissociative anesthesia. It has serious limitations in usefulness in animals. It is used routinely in cats and nonhuman primates, in combination with other agents and for short-term procedures.