NMDA receptors

NMDA receptors

Receptors for the NEUROTRANSMITTER n-methyl D-aspartate. This is a glutamate transmitter. Abnormally high levels of NDMA are thought to lead to neural dysfunction.
References in periodicals archive ?
The company has a proven platform for discovery of novel compounds that work through a unique mechanism to modulate -- rather than block or over-activate -- NMDA receptors and enhance synaptic plasticity, the foundation of neural cell communication.
In conjunction with the payment, Cadent had exclusively licensed the intellectual property for compounds that selectively modulate NR2B-containing NMDA receptors to Novartis.
NMDA receptors play an important role in drug addiction.
Conclusions: The data provide evidence for the involvement of NMDA receptors in producing the venom-induced vasosensory reflex responses modulating the cardiovascular parameters in anesthetized rats.
On the other hand, there is an impressive body of evidence that, unlike the hypofunction of NMDA receptors in schizophrenia, there appears to be increased activity of NMDA receptors in both unipolar and bipolar depression.
Furthermore, these observations are also in line with evidence that dysfunction of hippocampal NMDA receptors causes severe amnesia.
For instance, glutamatergic system changes, and number of NMDA receptors increases in this period.
Ketamine, a nociceptive antagonist of NMDA receptors, can prevent the induction of central sensitization caused by stimulation of peripheral nociception as well as blocking the wind-up phenomenon.
NMDA receptors control communication at many glutamate synapses.
It is hypothesized that the antibodies deplete cell-surface NMDA receptors on NMDA-receptor-rich neurons in the limbic system.
The new study shows, in the motor cortex this so-called synaptic plasticity no longer functions without the NMDA receptors.