NMDA receptors

NMDA receptors

Receptors for the NEUROTRANSMITTER n-methyl D-aspartate. This is a glutamate transmitter. Abnormally high levels of NDMA are thought to lead to neural dysfunction.
References in periodicals archive ?
Kaplin says that there's plenty of contrary evidence demonstrating that ketamine sticks to an entirely different receptor on brain cells: the NMDA receptors - involved in learning and memory - instead of the opioid receptors.
CTP-692 has been shown to have similar ability to bind to and activate human NMDA receptors relative to D-serine, with the potential for an improved renal safety profile and improved clinical outcomes in the treatment of schizophrenia.
It is evident that neurotransmission through NMDA receptors is deregulated in depression.
Glutamate dependent neurotoxicity via over-activated NMDA receptors as well, is a key pathogenic event that is a part of neurodegeneration (19).
In addition, Cadent has entered into an exclusive license and collaboration agreement with Novartis to develop a medicine that modulates NMDA receptors for the treatment of people with treatment resistant depression.
NMDA receptors are ionic channels highly permeable to calcium and increase intracellular calcium in neurons.
MK-801 is a non-competitive antagonist of glutamate NMDA receptors, and it induces behavioral hyperactivity in rodents (14).
Seeburg, "Developmental and regional expression in the rat brain and functional properties of four NMDA receptors," Neuron, vol.
In conjunction with the payment, Cadent had exclusively licensed the intellectual property for compounds that selectively modulate NR2B-containing NMDA receptors to Novartis.
On the other hand, there is an impressive body of evidence that, unlike the hypofunction of NMDA receptors in schizophrenia, there appears to be increased activity of NMDA receptors in both unipolar and bipolar depression.
The NMDA receptors require binding of glycine and glutamate simultaneously, as well as membrane depolarization for activation.
Convincing evidence demonstrates that the development of hyperalgesia and persistent pain involves activation of NMDA receptors in the spine [8, 9].