NMDA receptor antagonists

NMDA receptor antagonists

Drugs used in the hope of improving the mental condition of people with Alzheimer's disease and delaying progress. An example is memantine (Ebixa).
References in periodicals archive ?
Published in the International Journal of Neuropsychopharmacology, the preclinical research supports that rapastinel exhibited rapid and sustained antidepressant effects through positive modulation of the NMDA (N-methyl-D-aspartate) receptor and suggests that it may work differently from NMDA receptor antagonists like ketamine and S-ketamine (esketamine).
Therefore, it appears that NMDA receptor antagonists may be key to developing a new generation of improved treatments for major depression.
NMDA receptor antagonists may have potential in the treatment of a range of psychiatric and neurological disorders associated with a variety of cognitive, neurological and behavioral symptoms.
To the best of our knowledge, there is no human study that has evaluated the effects of the NMDA receptor antagonists on SAH-related neurocognitive damage.
Anticonvulsant effect of lithium chloride on the pentylenetetrazole-induced clonic seizure in mice: Interaction with voltage-dependent calcium channel and NMDA receptor antagonists. Epilepsy & Behavior.
[8] It is reported that peripherally administered NMDA receptor antagonists are involved with antinociception and anti-inflammatory cascade.
Most conventional nonselective NMDA receptor antagonists, however, have been implicated in adverse effects including psychotomimetic effects, impairments of learning, memory, and dissociative anesthesia.
Buonaguro et al., "Different effects of the NMDA receptor antagonists ketamine, MK-801, and memantine on postsynaptic density transcripts and their topography: role of Homer signaling, and implications for novel antipsychotic and pro-cognitive targets in psychosis," Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.
It is reported that treatment with NMDA receptor antagonists during early developmental stages leads to an increase both in locomotor activity and exploratory behaviors [18-20]; however, in our study there was a decrease in the locomotor activity and exploratory behaviors.
Consistently, several classes of compounds, such as, NMDA receptor antagonists and [GABA.sub.A] modulators, have been found to prevent the development of analgesic tolerance following both acute (Kissin et al.
Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.
NMDA receptor antagonists have been explored for many years as therapeutic agents for the treatment of neurological disorders such as stroke, epilepsy, pain, and Parkinson's disease.