NMDA antagonist

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NMDA antagonist

Neurology Any of a number of agents that protect against brain damage in neurologic disorders–eg, stroke; PCP–phencyclidine and ketamine are effective, but have psychotomimetic effects or damage neurons in the cerebral cortex; diazepam and barbiturates act at the GABA receptor channel complex, and may prevent the unwanted side effects of NMDA antagonists
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Food and Drug Administration has sanctioned the New Drug Application for Namzaric, a fixed-dose combination of memantine hydrochloride extended-release, a NMDA receptor antagonist, and donepezil hydrochloride, an acetylcholinesterase inhibitor.
Evotec's portfolio comprises five clinical compounds: EVT 101, a subtype selective NMDA receptor antagonist for the treatment of depression in partnership with Roche, EVT 201, a partial positive allosteric modulator (pPAM) of the GABAA receptor complex for the treatment of insomnia, EVT 302, a MAO-B inhibitor in development for smoking cessation, a P2X7 antagonist for the treatment of inflammatory diseases and a vanilloid receptor (VR1) antagonist for the treatment of pain in partnership with Pfizer.
It acts on mu, kappa, and delta opioid receptors and is an NMDA receptor antagonist.
Overstimulation of the N-methyl-Dasparatate (NMDA) receptors has been implicated in AD; an NMDA receptor antagonist such as memantine may serve as a suitable treatment.
Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease.
Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist.
These therapies include the acetylcholinesterase inhibitors (AChEIs) donepezil (Eisai/Pfizer's Aricept, generics), galantamine (Ortho-McNeil Neurologic's Razadyne, Razadyne ER, generics), and rivastigmine (Novartis's Exelon, generics, and the Exelon patch) as well as the NMDA receptor antagonist memantine (Forest Laboratories' Namenda).
The observation that users of the drug phencyclidine--also known as PCP or angel dust--an NMDA receptor antagonist, experienced schizophrenialike symptoms led several years ago to the prediction that an endogenous NMDA receptor antagonist would be found in the human brain and that levels would be altered in schizophrenia patients, said Dr.
And memantine, an NMDA receptor antagonist, is thought to ameliorate excessive activation of these receptors, which may explain how it works, according to Forest.
Memantine is the first NMDA receptor antagonist to show efficacy in Alzheimer's disease and vascular dementia.
Biton B, Granger P, Carreau A, Depoortere H, Scatton B, Avenet P: The NMDA receptor antagonist eliprodil (SL 82.