NMDA


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NMDA

Abbreviation for N-methyl-d-aspartate; an excitotoxic amino acid used to identify a specific subset of receptors of glutamate (an excitatory amino acid).

NMDA

N-methyl-D-asparate
References in periodicals archive ?
It runs contrary to a textbook tenet that has prevailed for more than 15 years, namely that NMDA receptors in the CA1 region of the hippocampus are needed to develop spatial memory.
pretreatment with HK significantly increased the threshold of NMDA seizure (Lin et al.
He and his colleagues vaccinated rats with a virus that had been genetically engineered to produce a fragment of the NMDA receptor, and the rats developed antibodies to this protein.
To determine their role in habit formation, GHSU researchers used a genetic trick to selectively disable the NMDA receptors on dopamine neurons and found, for example, mice could be trained to push a lever for food without it becoming an automatic response.
1982; Brodin and Roed, 1984; Kozam and Newark, 1997) and inhibits excitotoxicity induced by NMDA receptors activation (Wie et al.
The two main glutamate receptors in the brain are NMDA and AMPA receptors, both of which play critical roles in human learning and memory.
If so, then those compounds might be NMDA antagonists with a therapeutically beneficial profile.
This effect was thought to be related to differential expression of NMDA receptor subtypes during this period.
Chuang's team also examined the role of the NMDA receptor, the cell surface protein that glutamate binds to when it excites a cell.
NMDA receptors are located in the central nervous system and play a role in the perception of acute and chronic pain.
Molecules discovered by Naurex achieve this through a novel mechanism that modulates the NMDA receptor C rather than shutting it down C resulting in drugs that are both highly effective and well tolerated.