NMDA


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NMDA

Abbreviation for N-methyl-d-aspartate; an excitotoxic amino acid used to identify a specific subset of receptors of glutamate (an excitatory amino acid).
References in periodicals archive ?
These NMDA receptors are found together with the opioid receptors on brain cells, and Kaplin says it's no surprise that their components can meddle with one another, like interference picked up on a phone call or on the radio.
An extensive body of evidence supports NMDA receptor hypofunction as a key underlying mechanism of schizophrenia.
Other antagonists of glutamate NMDA receptors like ketamine[14] topiramate[15] have showed antidepressant effects.
To evaluate the effects of ATX on NMDA subunits, LVSCC-A1C, LVSCC-A1D, calbindinD28k and parvalbumin mRNA expression levels, primary cortical neurons were incubated with ATX at 10nM and 20nM concentration for different time stops such as 4 hours, 24 hours and 48 hours.
Another promising NMDA antagonist, rapastinel, is wending its way through clinical trials--but should it be approved, its use might be limited by the requirement for intravenous delivery.
Simvastatin was also shown to upregulate NMDA receptor binding, and to possess hyperlocomotive and anxiolytic-like activities (9).
AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors (AMPARs and NMDARs, resp.) are crucial in activity-dependent synaptic changes (reviewed in [2-5]).
The company's proposed first lead product, QRX001, is a single use transdermal non-competitive NMDA receptor antagonist intended for the treatment of post-surgical pain.
Anti-N-methyl-D-aspartate (NMDA)--receptor encephalitis is an immune-mediated neurological disorder caused by production of antibodies to the NMDA receptor leading to a syndrome of psychosis, movement disorder, neurologic deterioration and autonomic dysfunction (1, 2).