NLRP6

NLRP6

A gene located on chromosome 11p15 that encodes a cytoplasmic protein of the NALP protein family, which is thought to activate CASP1 and promote activation of NF-kappa-B.
Mentioned in ?
References in periodicals archive ?
Kau et al., "NLRP6 inflammasome regulates colonic microbial ecology and risk of colitis," Cell, vol.
There have been seven established NLRs that form an inflammasome complex: NLRP1 (NALP1), NLRP3 (NALP3 or cryopyrin), NLRP6, NLRP12, NLRC4 (with caspase recruitment domain or IPAF), AIM2 (absent in melanoma-2), and RIG-1 (retinoic acid inducible gene-1); however, the NLRP3 inflammasome is the best characterized in relation with renal diseases [40].
Each NLR molecule (NLRP1, NLRP3, NLRP6, NLRP7, NLRP12, or NAIP/NLRC4) recognizes specific ligands that activate the assembly of the inflammasome.
in 2011 indicated that NLRP6 inflammasome deficient mice were characterized by inflammatory cell recruitment and exacerbation of intestinal colitis induced by exposure to DSS.
actinomycetemcomitans up regulates NLRP3, IL 1[beta] and down regulates NLRP6 in peripheral mononuclear leukocytes.
Con respecto a las NLRs, son una familia de 23 proteinas codificadas en el genoma humano, las cuales contienen un dominio de union de nucleotidos y un dominio repetido rico en leucina (que incluye: NALP, NOD, PYPAF y CATERPILLER); hasta ahora, se han identificado 8 miembros de estas 23 proteinas con capacidad para formar los inflamasomas, a saber: la proteina NLRP1, la NLRP3, la NLRP6, la NLRP12, la NLRP2, la NLRC4, la ALR (receptor tipo AIM-2 o ausente en melanoma 2) y el sensor citoplasmatico RIG-1.
Forhead et al., "Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine," American Journal of Physiology--Gastrointestinal and Liver Physiology, vol.
A latest study showed that NLRP6 shaped the characteristic of intestinal flora and that the loss of NLRP6 induced more colitogenic microbiota to flourish (Elinav et al., 2011).
Stimulation of NOD1 and NOD2 also induces production of cytokines and chemokines, dependent on MAPK and NF-[kappa]B signaling, whereas activation of NLRs such as NLRC4, NLRP1, NLRP3, and NLRP6 culminates in the formation of inflammasomes.
In addition to NLR inflammasomes (NLRP1, NLRP3, NLRP6, NLRP12, and NLRC4), there are four additional inflammasomes (AIM2, RIG-I, IFI6, and PYRIN) which form by non-NLR sensor proteins [57].