negatively regulates autophagic processes through an association with beclin1," The Journal of Immunology, vol.
The NLR family, pyrin domain-containing 1 , 3 , 4 , and 12  (NLRP1, NLRP3, NLRP4
, and NLRP12, resp.), are NLRs that have been shown to be involved in inflammasome assembly, while AIM2 is the most well-characterized ALR.
Finally, NLRs, specifically NLRP3 and NLRP4
, have been found to be involved in alcoholic liver inflammation.
NLRPs are a subgroup of NLRs constituted by proteins such as NLRP1, NLRP3, NLRP4
, NLRP6, NLRP7, and NLRP12 that are involved in the formation of multiprotein complexes termed inflammasomes .