NLRP4

NLRP4

A gene located on chromosome 19q13.43 that encodes a cytoplasmic protein that is thought to activate proinflammatory caspases.
Mentioned in ?
References in periodicals archive ?
Takeshita, "NLRP4 negatively regulates autophagic processes through an association with beclin1," The Journal of Immunology, vol.
The NLR family, pyrin domain-containing 1 [13], 3 [14], 4 [15], and 12 [16] (NLRP1, NLRP3, NLRP4, and NLRP12, resp.), are NLRs that have been shown to be involved in inflammasome assembly, while AIM2 is the most well-characterized ALR.
Finally, NLRs, specifically NLRP3 and NLRP4, have been found to be involved in alcoholic liver inflammation.
NLRPs are a subgroup of NLRs constituted by proteins such as NLRP1, NLRP3, NLRP4, NLRP6, NLRP7, and NLRP12 that are involved in the formation of multiprotein complexes termed inflammasomes [80].