NLRP3

NLRP3

A gene located on chromosome 1q44 that encodes a pyrin-like protein that interacts with the apoptosis-associated speck-like protein PYCARD/ASC. NLRP3 has a caspase recruitment domain, and belongs to the NALP3 inflammasome complex; it plays a role in regulating inflammation and apoptosis.
 
Molecular pathology
NLRP3 mutations are associated with chronic infantile neurological cutaneous and articular (CINCA) syndrome, familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease (NOMID).
References in periodicals archive ?
Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production.
Recently, we and others have shown that the activation of purinergic P2X7 receptors (P2X7R) in immune cells is a novel and increasingly validated pathway to initiate inflammation through the activation of the NLRP3 inflammasome and the release of IL-1E- and IL-18 cytokines.
The scientists described how a compound called BHB ([beta]-hydroxybutyrate) can inhibit NLRP3, which is part of a complex set of proteins called inflammasomes, which drive inflammatory responses in many disorders.
Caspase 1 (CASP1) and NLRP3 were among the genes with increased activity in steroid-resistant cells.
In their study, published in online issue of Nature Medicine, the researchers described how the compound β-hydroxybutyrate (BHB) directly inhibits NLRP3, which is part of a complex set of proteins called the inflammasome.
10:30 NLRP3 INFLAMMASOME'S ROLE IN IL40K0 MICE FOL- LOWING CHLAMYDIA INFECTION, DN McKeithen*, Y Omo-sun, EC Kibakaya , F Eko, CM Black, JU Igietseme, GA Ananaba and Q He
Similar CDCs have been shown to have intracellular activity capable of up regulation of the innate immune system and activation of the NLRP3 inflarnmasome.
Using different mouse models of inflammasome deficiency, such as mice deficient in Asc (apoptosis-associated speck-like protein containing a caspase recruitment domain), NLRP3 (nucleotide-binding domain, leucine rich family, pyrin containing 3), caspase, or interleukin 18, the authors showed significant alterations in gut microbiota as evidenced by increased members of Bacteriodetes and decreased members of Firmicutes in these mouse models.
Pyrin domain containing 3 (NLRP3), coding NLRP3 protein, is a member of the NALP subfamily in the CATERPILLER family (Ting et al.
Another paper published in the journal Cell showed that when these RNAs build up in the eye they trigger activation of an immune complex known as the NLRP3 inflammasome.
The data showed elevated fatty acid as a result of HFD can activate the NLRP3 inflammasome in macrophages.