NLRP3

NLRP3

A gene located on chromosome 1q44 that encodes a pyrin-like protein that interacts with the apoptosis-associated speck-like protein PYCARD/ASC. NLRP3 has a caspase recruitment domain, and belongs to the NALP3 inflammasome complex; it plays a role in regulating inflammation and apoptosis.
 
Molecular pathology
NLRP3 mutations are associated with chronic infantile neurological cutaneous and articular (CINCA) syndrome, familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and neonatal-onset multisystem inflammatory disease (NOMID).
References in periodicals archive ?
AC-203 is a proprietary topical formulation of 1% diacerein, which has shown the ability to inhibit the production and activity of caspase-1 and the cytokine Interleukin-1Beta (IL-1Beta) through the inhibition of the assembly of the NLRP3 inflammasome.
According to the company, AC-203 is a proprietary topical formulation of 1% diacerein, which has shown the ability to inhibit the production and activity of caspase-1 and the cytokine Interleukin-1Beta (IL-1Beta) through the inhibition of the assembly of the NLRP3 inflammasome.
These differences may be driven by the NLRP3 gene, which, in the presence of neuronal insults such as beta-amyloid aggregates, can direct microglia to pump out a stew of inflammatory cytokines and chemokines, Dr.
How exactly the NLRP3 inflammasome recognizes the exposure of the body to Western type diets remains to be determined.
CAPS are a spectrum of diseases arising from the gain of function mutations in NLRP3, a key component of the inflammasome, resulting in elevated systemic IL-beta levels.
Recientemente se ha demostrado que las HDL tienen la capacidad de disminuir la secrecion de IL-1 en repuesta al estimulo con cristales de colesterol en macrofagos derivados de monocitos y la linea celular TPH-1; esta reduccion podria asociarse con la capacidad de las HDL de modular negativamente la expresion transcripcional de NLRP3 e IL-1 [beta], asi como de inducir una mayor estabilidad de la membrana lisosomal reduciendo la activacion de la caspasa-1 y el dano mitocondrial (27).
NLRP3 inflammasomes have been shown to play a crucial role in the pathogenesis of coxsackievirus B3-induced myocarditis (36).
Smoking, exposure to diesel fuel, inhalation of asbestos or other silicates--these cause inflammation which activates the NLRP3 inflammasome, but in the pulmonary system rather than the arteries," Dr.
BMY said the acquisition will give it full rights to IFM's preclinical STING (stimulator of interferon genes) and NLRP3 agonist programmes focused on enhancing the innate immune response for treating cancer, and is an example of Bristol-Myers Squibb's continued focus on leveraging external innovation to expand and develop its portfolio of transformative medicines.
The transaction includes full rights to IFMs preclinical STING (stimulator of interferon genes) and NLRP3 agonist programs focused on enhancing the innate immune response for treating cancer.