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ATP binding by monarch-1/ NLRP12 is critical for its inhibitory function.
Investigators showed that the protein NLRP12 works in T cells to limit production of chemical messengers or cytokines that fuel inflammation.
Specially bred mice that received T cells deficient in the protein NLRP12 developed more severe symptoms of colitis and the chronic skin condition atopic dermatitis.
NLRP12 belongs to a family of proteins best known for working in the innate immune system to help cells sense threats and then launch the inflammatory response to eliminate them.
Previous research from Kanneganti's laboratory showed that rather than fueling production of the cytokines that drive inflammation, NLRP12 played a different role in the innate immune response.
Researchers showed that in the innate immune system, NLRP12 worked in the NF-kB signaling pathway to restrain inflammation.
Recently, an increasing number of papers concerning human inflammatory diseases have focused on NLRP12, a member of the NLR gene family.
NLRP12 acts as negative regulator of inflammation, and this function requires the assistance of ASC (apoptotic speck protein) (Wang et al.
NLRP12 is a checkpoint in the process of many inflammatory diseases.
In this study, we performed the case-control study to explore the association between NLRP12 polymorphisms and NSDD in New Zealand White rabbits.
NLRP12 mRNA expression and association with NSDD were subsequently investigated.
Recientemente se han propuesto dos nuevos inflamasomas, denominados NLRP6 y NLRP12, aunque su funcionalidad como tales aun requiere estudio (15-17).
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