NLRC5

NLRC5

A gene on chromosome 16q13 that encodes a protein which is a putative regulator of NF-kappaB and type-I and -II interferon signalling pathways; it plays a role in homeostatic control of innate immunity and in antiviral defence.
References in periodicals archive ?
Ma, "Dexmedetomidine (DEX) protects against hepatic ischemia/reperfusion (I/R) injury by suppressing inflammation and oxidative stress in NLRC5 deficient mice," Biochemical and Biophysical Research Communications, vol.
Other PTMs, such as acetylation (HDAC6) and SUMOylation (P1AS2[beta], TRIM38, and SENP2), or direct association of cellular proteins with RIG-I to disrupt its interaction with MAVS (NLRC5, NLRX1), have also been shown to contribute to RIG-I activation or repression.
Xia et al., "NLRC5 negatively regulates the NF-[kappa]B and type I interferon signaling pathways," Cell, vol.
NLRs (NLRP1, NLRP3, NLRC4, and NLRC5), pyrin and HIN domaintein (PYRIN), and absent in melanoma 2 (AIM2) are the major members of the inflammasome family [15].
The binding of these factors to the SXY module allows the further binding of the coactivator CIITA and the NOD-like receptor family CARD domain containing 5 (NLRC5) factors [25, 41, 42].
Biswas et al., "NLR family member NLRC5 is a transcriptional regulator of MHC class I genes," Proceedings of the National Academy of Sciences of the United States of America, vol.
Kufer, "NLRC5 controls basal MHC class I gene expression in an MHC enhanceosome-dependent manner," The Journal of Immunology, vol.