NLGN4X

(redirected from NLGN4)

NLGN4X

A gene on chromosome Xp22.33 that encodes neuroligin 4, a putative neuronal cell surface protein involved in cell–cell interactions.
 
Molecular pathology
Defects of NLGN4X have been linked to an increased susceptibility to Asperger syndrome (X-linked type 2) and to autism (X-linked type 2).
References in periodicals archive ?
Mutations of the x-linked genes encoding neurologins NLGN3 and NLGN4 are associated with autism.
So extending the assumption of X chromosome evolution from autosome we can assume that paralog of X-linked genes must be on autosome and should be involved in the same disorder; like ARHGEF6 (X chromosome) has its paralog ARHGEF3 and ARHGEF4 on autosome; similarly NLGN3, NLGN4 on X -chromosome has paralog NLGN1 and NLGN2 on autosome.
Paris Autism Research International Sibpair Study: Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.