NLGN3

NLGN3

A gene on chromosome Xq13.1 that encodes neuroligin 3, a neuronal cell surface protein involved in cell–cell interactions, which forms intercellular junctions by binding to beta-neurexins. It may play role in forming or maintaining synaptic junctions, as well as glia–glia or glia–neuron interactions in the developing peripheral nervous system.
 
Molecular pathology
Defects of NLGN3 have been linked to an increased susceptibility to Asperger syndrome (X-linked type 1) and to autism (X-linked type 1).
References in periodicals archive ?
Mutations of the x-linked genes encoding neurologins NLGN3 and NLGN4 are associated with autism.
So extending the assumption of X chromosome evolution from autosome we can assume that paralog of X-linked genes must be on autosome and should be involved in the same disorder; like ARHGEF6 (X chromosome) has its paralog ARHGEF3 and ARHGEF4 on autosome; similarly NLGN3, NLGN4 on X -chromosome has paralog NLGN1 and NLGN2 on autosome.
Paris Autism Research International Sibpair Study: Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.