ANGPTL4

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ANGPTL4

A gene on chromosome 19p13.3 that encodes angiopoietin-like protein 4, which is expressed in endothelial cells in response to hypoxia. It is directly involved in regulating glucose homeostasis, lipid metabolism and insulin sensitivity; it may act as a regulator of angiogenesis and modulate tumourigenesis, and may protect endothelial cells by secreted factors. It reduces endothelial cell motility and inhibits sprouting and tube formation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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AMATEURS Thornhill Trojans yesterday provided the first major shock of the Powergen Challenge Cup by beating NL2 side Workington Town 16-12, with fullback Craig Holmes notching 12 points.
The Crusaders are second in NL2 with a game in hand and are preparing for tomorrow's clash against league leaders Featherstone Rovers, a game and can be seen live on Sky Sports (7.35pm).
Top prop Line is set join NL2 rivals Swinton Lions, while Fijian packman Tabua Cakacaka recently signed for York City Knights.
Record points scorer Chris Birch has failed to reproduce last year's form which made him the only Gateshead player named in the NL2 Team of the Year.
Now NL2 players do not earn a king's ransom - not far above ten bob a game with a bag of chips on the way home thrown in.
York, like Oldham, were relegated from National League One last season but have had a poor start to their NL2 campaign, winning just one out of their first five matches.
Thomas's last NL2 away game will ironically be at London Skolars this weekend after a Challenge Cup defeat in the capital earlier in the season almost cost him his job.
"We set our standards in our first NL2 game at the Thunderdome against Workington, when we won 54-6 in what was a fine all-round performance," he said.
Thunder are again without suspended scrum-half or stand-off Chris Birch, who will return to action in next week's NL2 clash against Hunslet Hawks at Kingston Park.
The Hawks finished fourth in last year's NL2 while Featherstone are tipped to reclaim their first division place at the first time of asking.
Van Dijk has had a tremendous season with the Crusaders, who reached the final eliminator in NL2 this year and just failed to qualify for the play-off final after losing to a golden point extra-time drop goal against Swinton Lions on Sunday.